Estimation of the risk for radiation-induced liver disease following photon- or proton-beam radiosurgery of liver metastases

Table 2 Values of the LKB-model parameters, the corresponding biological-endpoints and the LQ-model parameter for all OARs

OAR	n	m	TD ₅₀ (Gy)	Endpoint	α/β (Gy)	Sources
Skin	0.38	0.14	39	Radiation-induced skin toxicity	3^a	Pastore et al. (2016) [31]
Lung	1	0.41	29.9	Symptomatic radiation pneumonitis	3	Semenenko & Li (2008) [32]
Liver	0.97	0.12	45.8	Radiation-induced liver disease (RILD)	2	Dawson et al. (2002) [2]
Spinal cord	0.05	0.175	66.5	Radiation myelitis	0.87^b	Burman et al. (1991) [33]
Right kidney	0.70	0.10	28	Clinical nephritis	3^a	Burman et al. (1991) [33]

^aValues of the assumed α/β parameter for these OARs; ^bthe value of the α/β parameter for the spinal cord was taken from Schultheiss (2008) [34]

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