Table 2 Comparison of dose to PTV for 4 planning treatment: PTV66, PTV FDG 70%, PTV F-miso, PTV FDG 42 Gy
From: FDG and FMISO PET-guided dose escalation with intensity-modulated radiotherapy in lung cancer
Scenario | Boost target volume | Mean doses (SE) to target volumes | ||||
|---|---|---|---|---|---|---|
PTV66 | PTV FDG 70% | PTV FMISO | PTV FDG 42Gy | p value | ||
Reference plan (66Gy) | 62.3 (± 0.38) | 66.5 (± 0.33) | 66.1 (± 0.32) | 66.1 (± 0.32) | NA | |
Scenario 2 | FDG Hotspot | 62.7 (± 0.4) | 72.5 (± 0.25) | 67.9 (± 0.49) | 67.9 (± 0.52) | 0.001 |
Scenario 3 | Fmiso | 62.6 (± 0.42) | 70.4* (± 0.74) | 72.2* (± 0.27) | 69.5 (± 0.74) | 0.001 |
Scenario 4 | FDG per treatment | 63.7 (± 0.36) | 71.9* (± 0.61) | 69.8 (± 0.61) | 73.1* (± 0.3) | 0.001 |