From: Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment
Structure | Clinical endpoint | Reference | Median (range) | p-value< 0.05d | |||
---|---|---|---|---|---|---|---|
Manual-BF | Pinnacle3Auto-Planning | ||||||
1 | AP-BF | AP-ARC | 1vs.2, 3 | 2vs.3 | |||
2 | 3 | ||||||
 |  |  | NTCP (%) | ||||
Heart | Valvular defects | Cella et al. (2013) | 26.71 (0.96–82.63) | 21.14 (0.96–84.21) | 16.09 (0.94–81.36) | – | – |
Lungs | Radiation fibrosisa | Cella et al. (2015)b | 5.85 (2.72–8.39) | 6.41 (2.19–8.03) | 5.53 (1.30–7.51) | 1 < 2 | 2 > 3 |
Cella et al. (2015)c | 6.05 (3.33–16.79) | 3.88 (3.21–7.87) | 4.80 (3.22–7.94) | 1 > 2,3 | 2 < 3 | ||
Thyroid | Hypothyroidism | Cella et al. (2012) | 3.22 (2.08–9.98) | 3.16 (2.15–4.36) | 2.62 (1.78–3.58) | – | – |
 |  |  | RRR | ||||
Heart | Major coronary events | van Nimwegen et al. (2015) | 1.28 (1.01–1.64) | 1.24 (1.01–1.53) | 1.22 (1.01–1.47) | 1 > 2,3 | 2 > 3 |
 |  |  | OR |  |  | ||
LAD | Coronary stenosis | Moignier et al. (2015) | 1.06 (1.00–3.43) | 1.04 (1.00–1.77) | 1.05 (1.00–1.93) | 1 > 2 |  |