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Table 5 Risk analysis for different organs and endpoints for manual and automated plans

From: Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment

Structure

Clinical endpoint

Reference

Median (range)

p-value< 0.05d

Manual-BF

Pinnacle3Auto-Planning

1

AP-BF

AP-ARC

1vs.2, 3

2vs.3

2

3

   

NTCP (%)

Heart

Valvular defects

Cella et al. (2013)

26.71 (0.96–82.63)

21.14 (0.96–84.21)

16.09 (0.94–81.36)

–

–

Lungs

Radiation fibrosisa

Cella et al. (2015)b

5.85 (2.72–8.39)

6.41 (2.19–8.03)

5.53 (1.30–7.51)

1 < 2

2 > 3

Cella et al. (2015)c

6.05 (3.33–16.79)

3.88 (3.21–7.87)

4.80 (3.22–7.94)

1 > 2,3

2 < 3

Thyroid

Hypothyroidism

Cella et al. (2012)

3.22 (2.08–9.98)

3.16 (2.15–4.36)

2.62 (1.78–3.58)

–

–

   

RRR

Heart

Major coronary events

van Nimwegen et al. (2015)

1.28 (1.01–1.64)

1.24 (1.01–1.53)

1.22 (1.01–1.47)

1 > 2,3

2 > 3

   

OR

  

LAD

Coronary stenosis

Moignier et al. (2015)

1.06 (1.00–3.43)

1.04 (1.00–1.77)

1.05 (1.00–1.93)

1 > 2

 
  1. Abbreviations: LAD Left Anterior Descending artery, NTCP Normal Tissue Complication Probability, RRR Relative Risk Ratio, OR Odds Ratio
  2. aComputed assuming an age of 30 years at time of irradiation; bModel including lungs D2%; cModel including left lung V5Gy; dFriedman and Dunn test