Table 4 Dosimetric indices and comparative analysis for Planning Target Volume (PTV) and different organs at risk for manual and automated plans
From: Auto- versus human-driven plan in mediastinal Hodgkin lymphoma radiation treatment
Structure | Dose Index | Median (range) | p-value< 0.05a | |||
|---|---|---|---|---|---|---|
Manual-BF | Pinnacle3Auto-Planning | |||||
1 | AP-BF | AP-ARC | 1vs.2,3 | 2vs.3 | ||
2 | 3 | |||||
PTV | HI | 0.12 (0.09–0.16) | 0.16 (0.1–0.22) | 0.13 (0.09–0.18) | 1 < 2 | 2 > 3 |
CI | 0.95 (0.94–0.96) | 0.95 (0.94–0.95) | 0.95 (0.95–0.97) | – | – | |
Heart | Dmean (Gy) | 3.8 (0.2–8.7) | 3.3 (0.2–7.2) | 3 (0.1–6.3) | 1 > 2,3 | 2 > 3 |
D2% (Gy) | 28.4 (0.4–31.5) | 28.3 (0.4–31.3) | 26.8 (0.3–30.2) | 1 > 3 | 2 > 3 | |
Left Ventricle | Dmean (Gy) | 1 (0.1–3.1) | 0.7 (0.1–1.6) | 0.8 (0.1–1.7) | 1 > 2,3 | – |
LAD | D50% (Gy) | 1.3 (0.0–25.7) | 0.8 (0.0–11.9) | 1 (0.0–13.7) | 1 > 2 | – |
Lungs | Dmean (Gy) | 6.3 (1.6–9.2) | 4.5 (1.4–5.9) | 4.6 (1.4–6.0) | 1 > 2,3 | – |
V5Gy (%) | 32.0 (7.5–52.4) | 20.9 (6.3–29.0) | 23.7 (7.7–35.0) | 1 > 2 | 2 < 3 | |
V20Gy (%) | 11.6 (2.6–18.5) | 8.4 (2.0–12.3) | 7.2 (1.0–9.7) | 1 > 3 | 2 > 3 | |
Thyroid | Dmean (Gy) | 16.8 (11.9–28.4) | 15.4 (10.1–25.7) | 15.5 (9.6–21.2) | 1 > 2,3 | – |
V30Gy (%) | 19.6 (7.9–51.3) | 19.2 (8.7–27.9) | 14.0 (3.7–22.5) | – | – | |
Breast | Dmean (Gy) | 1.1 (0.1–2.3) | 0.4 (0.1–1.2) | 0.6 (0.1–1.6) | 1 > 2,3 | 2 < 3 |
Normal Tissue | Dmean (Gy) | 2.9 (1.5–5.4) | 2.4 (1.4–3.8) | 2.4 (1.2–3.7) | 1 > 2 |  |