Table 6 Duodenal dosimetry and treatment factors for patients with Grade 3+ toxicity
Grade 3+ Toxicity | Treatment Factors | Duodenal Dosimetry | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Fids | PTV | Prescribed Dose | Dur’n | D0.035 cc | D1.0 cc | D5.0 cc | D10.0 cc | V15 Gy | V20 Gy | |
ACUTE | ||||||||||
Grade 3 pain | 4 | 39.84 cc | 30.0 Gy 3 fractions | 3 days | 33.9 Gy* | 25.4 Gy | 15.8 Gy | 12.8 Gy* | 5.9 cc | 2.5 cc |
Grade 3 fatigue | 3 | 44.22 cc | 30.0 Gy 3 fractions | 3 days | 34.9 Gy* | 27.9 Gy | 20.5 Gy* | 16.2 Gy* | 12.3 cc | 5.4 cc |
Grade 3 obstructive jaundice | 4 | 119.57 cc | 21.0 Gy 3 fractions | 3 days | 23.8 Gy* | 22.6 Gy | 21.1 Gy* | 19.6 Gy* | 32.2 cc | 8.6 cc |
LATE | ||||||||||
Grade 4 duodenal stricture | 1† | 20.34 cc | 28.5 Gy 3 fractions | 5 days | 11.2 Gy | 8.3 Gy | 6.8 Gy | 6.2 Gy | 0.0 cc | 0.0 cc |
Grade 4 GI bleed | 1† | 83.49 cc | 27.0 Gy 3 fractions | 5 days | 29.3 Gy* | 28.3 Gy | 26.2 Gy* | 23.9 Gy* | 39.1 cc | 19.4 cc |
Grade 4 GI bleed | 3 | 109.31 cc | 22.0 Gy 3 fractions | 3 days | 24.2 Gy* | 23.2 Gy | 22.5 Gy* | 21.8 Gy* | 63.3 cc | 24.3 cc |
Grade 4 duodenal stricture | 3 | 104.25 cc | 27.0 Gy 3 fractions | 3 days | 31.6 Gy* | 29.1 Gy | 26.0 Gy* | 21.8 Gy* | 24.2 cc | 12.8 cc |