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Table 5 Survival outcomes of submandibular gland carcinoma patients bearing adverse pathological risk factors, treatment with or without postoperative bilateral elective nodal irradiation

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Variable

 

RC (%)

DMFS (%)

DFS (%)

OS (%)

N

5-y

10-y

P

5-y

10-y

P

5-y

10-y

P

5-y

10-y

P

Entire cohort

 Extended ENI

18

90.0

90.0

0.207

59.3

59.3

0.700

59.3

59.3

0.871

70.3

61.6

0.636

 Limited ENI

47

76.6

76.6

 

67.6

67.6

 

65.4

65.4

 

72.3

63.6

 

pN+

 Extended ENI

9

100

100

0.003

51.9

51.9

0.166

51.9

51.9

0.034

44.4

44.4

0.333

 Limited ENI

9

0

–

 

12.5

–

 

0

–

 

27.8

0

 

Extranodal extension

 Extended ENI

6

100

100

0.022

44.4

44.4

0.328

44.4

44.4

0.161

50.0

50.0

0.319

 Limited ENI

6

20.0

–

 

0

–

 

0

–

 

0

–

 

pT3–4

 Extended ENI

8

100

100

0.044

40.0

40.0

0.694

40.0

40.0

0.579

37.5

18.8

0.288

 Limited ENI

18

41.0

41.0

 

32.7

32.7

 

34.3

34.3

 

49.1

32.8

 

Lymphovascular invasion

 Extended ENI

9

80.0

80.0

0.014

32.4

32.4

0.472

32.4

32.4

0.351

55.6

44.4

0.392

 Limited ENI

9

25.0

25.0

 

25.0

25.0

 

25.0

25.0

 

33.3

22.2

 

Perineural invasion

 Extended ENI

9

80.0

–

0.353

25.9

–

0.195

25.9

–

0.300

55.6

41.7

0.270

 Limited ENI

26

66.3

66.3

 

57.0

57.0

 

52.6

52.6

 

69.4

52.9

 

Margin < 1 mm

 Extended ENI

12

83.3

83.3

0.512

61.1

61.1

0.905

61.1

61.1

0.763

71.4

53.6

0.374

 Limited ENI

35

78.0

78.0

 

70.3

70.3

 

66.8

66.8

 

77.1

65.4

 

High grade histology

 Extended ENI

41

88.9

88.9

0.179

63.3

63.3

0.899

63.3

63.3

0.650

68.4

58.6

0.721

 Limited ENI

17

73.1

73.1

 

63.0

63.0

 

60.4

60.4

 

68.6

58.8

 

0 risk factora

 Extended ENI

6

100

100

–

100

100

0.533

100

100

0.533

100

100

0.449

 Limited ENI

26

100

100

 

91.1

91.1

 

91.1

91.1

 

87.9

87.9

 

≥1 risk factora

 Extended ENI

12

85.7

85.7

0.039

43.2

43.2

0.558

43.2

43.2

0.349

58.3

48.6

0.752

 Limited ENI

21

45.1

45.1

 

38.2

38.2

 

31.5

31.5

 

52.4

32.7

 

≥2 risk factorsa

 Extended ENI

11

83.3

83.3

< 0.001

36.8

36.8

0.019

36.8

36.8

0.007

54.5

43.6

0.117

 Limited ENI

8

14.3

–

 

0

0

 

0

0

 

16.7

0

 
  1. Abbreviations: DFS disease free survival, DMFS distant metastasis free survival, ENI elective nodal irradiation, OS overall survival, RC regional control
  2. aRisk factors: pN+, extranodal extension, pT3–4, and lymphovascular invasion