Variable | Â | RC (%) | DMFS (%) | DFS (%) | OS (%) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | 5-y | 10-y | P | 5-y | 10-y | P | 5-y | 10-y | P | 5-y | 10-y | P | |
Entire cohort | |||||||||||||
 Extended ENI | 18 | 90.0 | 90.0 | 0.207 | 59.3 | 59.3 | 0.700 | 59.3 | 59.3 | 0.871 | 70.3 | 61.6 | 0.636 |
 Limited ENI | 47 | 76.6 | 76.6 |  | 67.6 | 67.6 |  | 65.4 | 65.4 |  | 72.3 | 63.6 |  |
pN+ | |||||||||||||
 Extended ENI | 9 | 100 | 100 | 0.003 | 51.9 | 51.9 | 0.166 | 51.9 | 51.9 | 0.034 | 44.4 | 44.4 | 0.333 |
 Limited ENI | 9 | 0 | – |  | 12.5 | – |  | 0 | – |  | 27.8 | 0 |  |
Extranodal extension | |||||||||||||
 Extended ENI | 6 | 100 | 100 | 0.022 | 44.4 | 44.4 | 0.328 | 44.4 | 44.4 | 0.161 | 50.0 | 50.0 | 0.319 |
 Limited ENI | 6 | 20.0 | – |  | 0 | – |  | 0 | – |  | 0 | – |  |
pT3–4 | |||||||||||||
 Extended ENI | 8 | 100 | 100 | 0.044 | 40.0 | 40.0 | 0.694 | 40.0 | 40.0 | 0.579 | 37.5 | 18.8 | 0.288 |
 Limited ENI | 18 | 41.0 | 41.0 |  | 32.7 | 32.7 |  | 34.3 | 34.3 |  | 49.1 | 32.8 |  |
Lymphovascular invasion | |||||||||||||
 Extended ENI | 9 | 80.0 | 80.0 | 0.014 | 32.4 | 32.4 | 0.472 | 32.4 | 32.4 | 0.351 | 55.6 | 44.4 | 0.392 |
 Limited ENI | 9 | 25.0 | 25.0 |  | 25.0 | 25.0 |  | 25.0 | 25.0 |  | 33.3 | 22.2 |  |
Perineural invasion | |||||||||||||
 Extended ENI | 9 | 80.0 | – | 0.353 | 25.9 | – | 0.195 | 25.9 | – | 0.300 | 55.6 | 41.7 | 0.270 |
 Limited ENI | 26 | 66.3 | 66.3 |  | 57.0 | 57.0 |  | 52.6 | 52.6 |  | 69.4 | 52.9 |  |
Margin < 1 mm | |||||||||||||
 Extended ENI | 12 | 83.3 | 83.3 | 0.512 | 61.1 | 61.1 | 0.905 | 61.1 | 61.1 | 0.763 | 71.4 | 53.6 | 0.374 |
 Limited ENI | 35 | 78.0 | 78.0 |  | 70.3 | 70.3 |  | 66.8 | 66.8 |  | 77.1 | 65.4 |  |
High grade histology | |||||||||||||
 Extended ENI | 41 | 88.9 | 88.9 | 0.179 | 63.3 | 63.3 | 0.899 | 63.3 | 63.3 | 0.650 | 68.4 | 58.6 | 0.721 |
 Limited ENI | 17 | 73.1 | 73.1 |  | 63.0 | 63.0 |  | 60.4 | 60.4 |  | 68.6 | 58.8 |  |
0 risk factora | |||||||||||||
 Extended ENI | 6 | 100 | 100 | – | 100 | 100 | 0.533 | 100 | 100 | 0.533 | 100 | 100 | 0.449 |
 Limited ENI | 26 | 100 | 100 |  | 91.1 | 91.1 |  | 91.1 | 91.1 |  | 87.9 | 87.9 |  |
≥1 risk factora | |||||||||||||
 Extended ENI | 12 | 85.7 | 85.7 | 0.039 | 43.2 | 43.2 | 0.558 | 43.2 | 43.2 | 0.349 | 58.3 | 48.6 | 0.752 |
 Limited ENI | 21 | 45.1 | 45.1 |  | 38.2 | 38.2 |  | 31.5 | 31.5 |  | 52.4 | 32.7 |  |
≥2 risk factorsa | |||||||||||||
 Extended ENI | 11 | 83.3 | 83.3 | < 0.001 | 36.8 | 36.8 | 0.019 | 36.8 | 36.8 | 0.007 | 54.5 | 43.6 | 0.117 |
 Limited ENI | 8 | 14.3 | – |  | 0 | 0 |  | 0 | 0 |  | 16.7 | 0 |  |