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Table 1 Patient characteristics

From: Nodal failure patterns and utility of elective nodal irradiation in submandibular gland carcinoma treated with postoperative radiotherapy - a multicenter experience

Characteristic

N

%

Sex

 Female/Male

35/30

54/46

Age (years)

 Median (range)

53 (24–79)

Performance score

 ECOG 0–1

65

100

T stage

 pT1

15

23

 pT2

24

37

 pT3

20

31

 pT4a

6

9

Tumor size (cm)

 Median (range)

2.9 (0.5–8.0)

N stage

 pN0

6

9

 pN1

3

5

 pN2b

15

23

 cN0/pNxa

41

63

Disease stage

 I

13

20

 II

22

34

 III

11

17

 IVa

19

29

Staging modality

 CT

49

75

 MRI

6

9

 18F-FDG-PET

23

35

Surgical margin

 < 1 mm/≥1 mm

46/19

71/29

Histology

 Adenoid cystic carcinoma

29

45

 Carcinoma ex pleomorphic adenoma

11

17

 Mucoepidermoid carcinoma

8

12

 Lymphoepithelial carcinoma

6

9

 Squamous cell carcinoma

4

6

 Salivary duct carcinoma

4

6

 Adenocarcinoma

2

3

 Myoepithelial carcinoma

1

2

Histology grading

 Low to intermediate/High

6/59

9/91

Pathological features

 Perineural invasion

35

54

 Extranodal extension

12

19

 Bone invasion

2

3

 Skin invasion

1

2

 Lymphovascular invasion

18

28

Neck dissection

 None

41

63

 Ipsilateral elective

9

14

 Ipsilateral therapeutic

15

23

 Contralateral

0

0

 < 18 nodes

22

34

 ≥18 nodes

17

26

Nodal irradiation

 Extended ENI

18

28

 Limited ENI

47

72

Concurrent chemotherapy

24

37

 Radiotherapy technique

  3D-CRT

19

29

  IMRT

31

48

  VMAT

15

23

Radiotherapy dose (Gy)

 Median (range)

66 (32–72)

  1. Abbreviations: 3D-CRT three-dimensional conformal radiotherapy, CT computed tomography, ECOG Eastern Cooperative Oncology Group, ENI elective nodal irradiation, 18F-FDG-PET 18F-fluorodeoxyglucose positron emission tomography, IMRT intensity-modulated radiation therapy, MRI magnetic resonance imaging, VMAT volumetric modulated arc therapy
  2. a,no elective neck dissection in cN0 patients