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Table 1 Top 20 significantly differentially expressed protein coding genes between pRT responsive and non-responsive tumor samples

From: Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer

#

Gene Symbol

Gene Name

FDR-adjusted q-value

Fold Change

Super-Pathways

1

ST3GAL4

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

0.03715 ##

0.10

protein glycosylation

2

C6orf105 (ADTRP)

chromosome 6 open reading frame 105 (Androgen-Dependent TFPI-Regulating Protein)

0.03715 ##

0.17

No Data Available

3

RAP1GAP2

RAP1 GTPase activating protein 2

0.03781 ##

0.18

Immune System

4

A1CF

APOBEC1 complementation factor

0.03874 ##

0.17

mRNA Editing and Processing of Capped Intron-Containing Pre-mRNA

5

MAP3K4

mitogen-activated protein kinase kinase kinase 4

0.03874 ##

0.25

MAPK signaling pathway

6

CHD5

chromodomain helicase DNA binding protein 5

0.05133 #

0.15

ATP-dependent helicase activity

7

LAS1L

LAS1-like (S. cerevisiae)

0.05209 #

0.19

biogenesis of the 60S ribosomal subunit.

8

DEFB128

defensin, beta 128

0.05781 #

0.29

Immune System

9

ENHO

energy homeostasis associated

0.05781 #

0.23

metabolism

10

CECR9

cat eye syndrome chromosome region, candidate 9 (non-protein coding)

0.05781 #

0.20

unknown

11

IDO1

indoleamine 2,3-dioxygenase 1

0.05781 #

0.20

Tryptophan metabolism

12

LRRC55

leucine rich repeat containing 55

0.05788 #

0.14

ion channel

13

ROGDI

rogdi homolog (Drosophila)

0.05788 #

0.26

unknown

14

KRT25

keratin 25

0.05796 #

0.22

cytoskeleton

15

LAMA4

laminin, alpha 4

0.05798 #

0.25

Focal Adhesion, ECM-receptor interaction

16

PLA2G2C

phospholipase A2, group IIC

0.05798 #

0.15

alpha-Linolenic acid metabolism and Glycerophospholipid biosynthesis

17

CCDC114

coiled-coil domain containing 114

0.05798 #

0.25

cell motility

18

CNGB1

cyclic nucleotide gated channel beta 1

0.05798 #

0.27

cAMP binding and intracellular cAMP activated cation channel activity

19

PRSS53

protease, serine, 53

0.05798 #

0.30

serine-type endopeptidase activity

20

GSG1

germ cell associated 1

0.05798 #

0.22

RNA polymerase binding

  1. FDR – false discovery rate; Fold change is shown on a linear scale
  2. #q-value < 0.1; ##q-value < 0.05
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Radiation Oncology

ISSN: 1748-717X

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