|
Study
|
No. of Patients
|
Therapy
|
Median RT Dose Gy or CGE
|
Median Follow-Up Years
|
Toxicity Grading Scale
|
G3+ GU Toxicity
|
G2+ GU Toxicity
|
G3+ GI Toxicity
|
G2+ GI Toxicity
|
|---|
|
Liauw et al., 2009 [21]
|
130
|
IMRT
|
76
|
4.4
|
RTOG
|
6%b
|
37.0%b
|
5%b
|
14.0%b
|
|
Spratt et al., 2013 [22]
|
1002
|
IMRT
|
86.4
|
5.5
|
CTCAE
|
2.2%
|
8.5%
|
0.7%
|
2.0%
|
|
Vora et al., 2013 [23]
|
302
|
IMRT
|
75.6
|
7.6
|
CTCAE
|
2.6%
|
24.4%
|
1%
|
10.9%
|
|
Fang et al., 2015 [24]
|
94
|
IMRT
|
79.2
|
3.9
|
CTCAE
|
0%
|
18.3%
|
2.1%
|
10.8%
|
|
Fang et al., 2015 [24]
|
94
|
PS PBT
|
79.2
|
2.4
|
CTCAE
|
2.1%
|
12.8%
|
0%
|
12.8%
|
|
Slater et al., 2004 [17]
|
1255
|
PS PBT
|
74
|
5.3
|
RTOG
|
1.0%a
|
–
|
1.0%a
|
–
|
|
Pugh et al., 2013 [15]
|
291
|
PS > PBS PBT
|
76
|
2.0
|
RTOG
|
0%c
|
13.4%c
|
0.3%c
|
9.6%c
|
|
Mendenhall et al., 2014 [13]
|
211
|
PS PBT
|
78–82
|
5.2
|
CTCAE
|
1.0%a
|
–
|
0.5%a
|
–
|
|
Bryant et al., 2016 [9]
|
1215
|
PS PBT
|
78
|
5.5
|
CTCAE
|
2.9%a
|
–
|
0.6%a
|
–
|
|
Present study, 2017
|
192
|
PBS > PS PBT
|
79.2
|
1.7
|
CTCAE
|
1.0%
|
26.4%c
|
0.5%
|
21.3%c
|
- Abbreviations: PS passive scatter, PBS pencil beam scanning, PBT proton beam therapy, IMRT intensity-modulated radiation therapy, RTOG radiation therapy oncology group, CTCAE common terminology criteria for adverse events, version 4.0
- a = 5-year actuarial rate, b = 4-year actuarial rate, c = 2-year actuarial rate. No symbol next to a toxicity rate % indicates a rate reported as the number of toxicity events observed over the total number of patients, with varying median follow-up across studies
