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Table 3 Very hypo-fractionnated APBI discribed in the litterature

From: Single fraction of accelerated partial breast irradiation in the elderly: early clinical outcome

Authors Year # pts MFU (months) APBI techniques Total dose (Gy) D/f (Gy) AG3 to (%) LG3 tox (%) LF (%) RF (%) DM (%) Ex/good cosmetic result (%)
Sacchini 2008 18/34 31 HDRIORT 20/18 20/18 7.7 0 c
Khan 2013 30 11 Balloona 28 7 (BID) 0 0
Wilkinson 2012/17 45 74 Balloonb 28 7 (BID) 13.3 2 0 0 0 91
Showalter 2016 28 6 HDRIORT 12.5 12.5 0 93
Hannoun-Levi 2017 26 37 HDRMIB 16 16 7.6 0 0 0 88
Latorre 2018 20 24 HDRMIB 18 18 0 0 0 0 5 80
Present study 2018 48 40 HDRMIB 16 16 6.3 0 0 0 0 100
  1. aContura
  2. bMammosite
  3. cCosmetic results were better with 18 Gy compared to 20 Gy
  4. # Pts: number of patients; MFU: median follow-up; APBI: accelerated partial breast irradiation; HDRIORT: high-dose rate brachytherapy performed intraoperatively; MIB: multicatheter interstitial high-dose rate brachytherapy; D/f: dose per fraction; AG3 tox: acute ≥ Grade 3 toxicity; LG3 tox: late ≥ Grade 3 toxicity; LF: local failure; RF: regional failure; DM: distant metastasis; Ex/good cosmetic: percentages of excellent and good cosmetic results