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Table 1 Dose constraints

From: ONE SHOT - single shot radiotherapy for localized prostate cancer: study protocol of a single arm, multicenter phase I/II trial

Structure

Standardized nomenclature

Dosimetric Parameter

Per Protocol

Acceptable Variation

PTV_19

PTV_19

D98% (Dnear min)

≥ 95% (i.e. 18 Gy)

 

D2% (Dnear max)

≤ 107% (ie. 20.3Gy)

D5% ≤ 107%, D2% ≤ 110%

Rectal_wall

Rectal_wall

V9.5Gy (50%)

<  40%

40–50%

V15Gy (80%)

<  15%

15–20%

V17Gy (90%) (NTD 68 Gy)

<  10%

<  15%

V19Gy (100%) (NTD 83.6 Gy)

<  5%

<  10%

V20Gy (105%) (NTD 92 Gy)

<  1 cc

 

Bladder_wall

Bladder_wall

V9.5Gy (50%)

<  50%

50–60%

V15Gy (80%)

<  20%

20–30%

V17Gy (90%) (NTD 68 Gy)

<  15%

15–20%

V19Gy (100%) (NTD 83.6 Gy)

<  10%

<  15%

V20Gy (105%) (NTD 92 Gy)

<  1 cc

 

Femurs (each)

Femur_Rt

Femur_Lt

V14Gy (NTD 48 Gy)

<  5%

5–10%

Penile bulb

Penile_bulb

V14Gy (NTD 48 Gy)

<  5%

5–10%

Urethra PRV

Urethra_PRV

D98% (Dnear min)

≥ 95% (i.e. 16.2 Gy)

 

D5%

≤ 107% (i.e. 18.2 Gy)

 

D2% (Dnear max)

≤ 110% (i.e. 18.7 Gy)