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Table 3 Subgroup analysis and sensitivity analysis of ILNSI versus ILNPI

From: Feasibility of ipsilateral lower neck sparing irradiation for unilateral or bilateral neck node-negative nasopharyngeal carcinoma: systemic review and meta-analysis of 2, 521 patients

Outcomes No. of studies Pts receiving ILNSI (no.) Pts receiving ILNPI (no.) All pts. (no.) HR/OR (95% CI) P Study heterogeneity
χ2 df I2 (%) P
Subgroup analysis
 Studies using IMRT
  3-year OS 2 360 456 816 1.10 (0.69,1.74) 0.68 0.20 1 0 0.65
  3-year RRFS 3 414 556 970 1.11 (0.50,2.49) 0.80 1.26 2 0 0.53
  3-year DFS 2 243 457 700 0.92 (0.64,1.33) 0.67 26 1 26 0.24
  3-year DMFS 3 414 556 970 0.97 (0.62,1.51) 0.88 3.85 2 48 0.15
  ILN recurrence 3 414 556 970 1.44 (0.35,5.95) a 0.62 3.12 2 36 0.21
 Studies using 2D-RT
  3-year OS 2 176 207 383 1.35 (0.79,2.30) 0.27 0.29 1 0 0.59
  3-year DFS 2 176 207 383 1.41 (0.87,2.30) 0.17 0.15 1 0 0.70
  ILN recurrence 2 176 207 383 1.17 (0.16,8.32) a 0.88 0.02 1 0 0.90
Sensitivity analysis
 English publications
  3-year OS 4 602 634 1236 1.07 (0.73,1.57) 0.73 1.69 3 0 0.64
  3-year RRFS 5 571 1128 1699 1.27 (0.69,2.33) 0.44 2.48 4 0 0.65
  3-year DFS 2 243 457 700 0.92 (0.64,1.33) 0.67 26 1 26 0.24
  3-year DMFS 6 693 835 1528 1.00 (0.69,1.44) 0.99 3.98 5 0 0.55
  ILN recurrence 7 761 1377 2138 0.95 (0.44,2.09) a 0.91 5.64 6 0 0.46
 High-quality studies
  3-year OS 4 519 652 1171 1.02 (0.69,1.52) 0.92 1.44 3 0 0.70
  3-year RRFS 5 488 1146 1634 1.29 (0.71,2.37) 0.41 2.99 4 0 0.56
  3-year DFS 3 331 574 905 0.95 (0.67,1.34) 0.78 1.58 2 0 0.45
  3-year DMFS 4 485 635 1120 0.92 (0.62,1.36) 0.68 1.49 3 0 0.69
  ILN recurrence 6 641 1291 1932 1.05 (0.46,2.42) a 0.90 4.14 5 0 0.53
 Studies matched for T category
  3-year OS 5 689 811 1500 1.13 (0.82,1.55) 0.44 1.41 4 0 0.84
  3-year RRFS 5 570 1215 1785 1.20 (0.63,2.29) 0.54 2.81 4 0 0.59
  3-year DFS 4 419 664 1083 1.08 (0.80,1.44) 0.62 3.37 3 11 0.34
  3-year DMFS 5 604 805 1409 0.98 (0.67,1.44) 0.93 3.87 4 0 0.42
  ILN recurrence 7 811 1453 2264 1.06 (0.49,2.33) a 0.88 3.39 6 0 0.76
 Studies detecting LN metastases mainly by MRI
  3-year OS 4 602 634 1236 1.07 (073,1.57) 0.73 1.69 4 0 0.64
  3-year RRFS 4 503 586 1089 1.37 (0.68,2.76) 0/38 2.31 3 0 0.51
  3-year DFS 4 419 664 1083 1.08 (0.80,1.44) 0.62 3.37 3 11 0.34
  3-year DMFS 6 693 835 1528 1.00 (0.69,1.44) 0.99 3.98 5 0 0.55
  ILN recurrence 6 693 835 1528 1.05 (0.37,2.96) a 0.93 5.58 5 10 0.35
  1. Abbreviations: No. number, pts. patients, HR hazard radio, ILNSI ipsilateral lower neck sparing irradiation, ILNPI ipsilateral lower neck prophylactic irradiation, ILN ipsilateral lower neck, OS overall survival, RRFS regional recurrence-free survival, DFS disease-free survival, DMFS distant metastasis-free survival, MRI magnetic resonance imaging, CT computed tomography, IMRT intensity-modulated radiation therapy, 2D-RT two-dimensional radiotherapy
  2. a OR