From: Hyperfractionated abdominal reirradiation for gastrointestinal malignancies
 | Local progression-free survival | Overall survival | ||||
---|---|---|---|---|---|---|
Factor | Hazard ratio | 95% Confidence interval | P-value | Hazard ratio | 95% Confidence interval | P-value |
Age at Reirradiation | ||||||
  < 65 | Reference | Reference |  | Reference | Reference |  |
  ≥ 65 | 0.72 | 0.27–1.89 | .501 | 0.60 | 0.24–1.48 | .268 |
Gender | ||||||
 Male | Reference | Reference |  | Reference | Reference |  |
 Female | 0.87 | 0.27–2.54 | .806 | 0.58 | 0.20–1.46 | .256 |
Primary Cancer | ||||||
 Pancreatic Adeno | Reference | Reference |  | Reference | Reference |  |
 Upper GI Adenoa | 1.14 | 0.24–4.07 | .856 | 1.36 | 0.20–4.60 | .650 |
 Colon Adeno | 1.12 × 10 –9* | 5.67 × 10 − 55 -.35 * | .002 * | 3.65 | 0.76–13.82 | .098 |
 Hepatobiliaryb | 0.78 | 0.17-2.72 | .715 | 1.02 | 0.23–3.44 | .976 |
 Otherc | 0.66 | 0.03-3.66 | .678 | 2.34 | 0.34–9.95 | .334 |
Initial RT dose | ||||||
  ≤ 45Gy | Reference | Reference |  | Reference | Reference |  |
  > 45Gy | 0.62 | 0.20–1.67 | .361 | 1.09 | 0.41–2.69 | .848 |
Interval between 1st and 2nd courses of RT | ||||||
  < 1 year | Reference | Reference |  | Reference | Reference |  |
  ≥ 1 year | 1.19 | 0.12–3.28 | .824 | 0.45 | 0.14–2.00 | .261 |
Type of post-1st RT disease | ||||||
 New Primary | Reference | Reference |  | Reference | Reference |  |
 Recurrence | 2.37 | 0.46–43.24 | .351 | 0.50 | 0.16–2.22 | .323 |
Reason for reirradiation | ||||||
 Definitive | Reference | Reference |  | Reference | Reference |  |
 Palliative | 1.42 | 0.48–3.80 | .510 | 3.38 | 1.24–9.03 | .018 |
Reirradiation dose | Â | Â | Â | Â | Â | Â |
  ≤ 30Gy | Reference | Reference |  | Reference | Reference |  |
  > 30Gy | 1.31 | 0.43–4.96 | .650 | 1.10 | 0.44–3.13 | .844 |
Reirradiation modality | ||||||
 3DCRT | Reference | Reference |  | Reference | Reference |  |
 IMRT | 0.62 | 0.21–1.64 | .342 | 0.84 | 0.31–2.06 | .708 |
Concurrent chemo with reirradiation? | ||||||
 No | Reference | Reference |  | Reference | Reference |  |
 Yes | 1.51 | 0.51–5.55 | .473 | 0.75 | 0.30–2.13 | .565 |