Radiation Oncology

Table 3 Univariate and multivariate analysis in both groups

From: The influence of fractionated radiotherapy on the stability of spinal bone metastases: a retrospective analysis from 1047 cases

	<= 10 fractions
	stable		instable		p-value	p-value (logistic Regression)
	n = 377		n = 392
	n	%	n	%
Age (years)
Mean (SD)	62.6 +/− 10.4		64.0 +/− 11.0		0.084^a	0.214
Gender
Male	219	55.9	216	57.3	0.690^a	0.742
Female	173	44.1	161	42.7
Karnofsky- Index
Median (range)	80 (40,100)		70 (40,100)		0.027^c	0.090
Primary site					0.933^b	0.883
NSCLC	183	46.7	173	45.9
Breast cancer	55	14.0	51	13.5
Renal cancer	42	10.7	46	12.2
Other	112	28.6	107	28.4
Localization metastases					0.303^b	0.637
Cervical/Thoracic	228	58.2	233	61.8
Lumbar	164	41.8	144	38.2
Number metastases					< 0.0001^b	< 0.0001
Solitary	210	53.6	140	37.1
Multiple	182	46.4	237	62.9
Other distant metastases
Liver	102	26.0	101	26.8	0.809^b	0.518
Brain	59	15.1	53	14.1	0.697^b	0.759
Lung	95	24.2	90	23.9	0.907^b	0.902
Tissue	35	8.9	20	5.3	0.051^b	0.120
	> 10 fractions
	stable		instable		p-value	p-value (log. Regression)
	n = 121		n = 157
	n	%	n	%
Age (years)
Mean (SD)	60.7 +/− 12.7		63.8 +/− 11.3		0.034^a	0.168
Gender
Male	60	49.6	83	52.9	0.588^a	0.643
Female	61	50.4	74	47.1
Karnofsky- Index
Median (range)	80 (40,100)		70 (30,100)		0.063^c	0.079
Primary site					0.575^b	0.933
NSCLC	28	23.1	41	26.1
Breast cancer	28	23.1	41	26.1
Renal cancer	30	24.8	41	26.1
Other	35	28.9	34	21.7
Localization metastases					0.687^b	0.970
Cervical/Thoracic	75	62.0	101	64.3
Lumbar	46	38.0	56	35.7
Number metastases					0.662^b	0.834
Solitary	61	50.4	75	47.8
Multiple	60	49.6	82	52.2
Other distant metastases
Liver	32	26.6	28	17.8	0.084^b	0.965
Brain	17	14.1	13	8.3	0.129^b	0.274
Lung	45	37.2	29	18.5	< 0.001^b	0.013
Tissue	8	6.6	4	2.6	0.098^b	0.406

Abbreviation: ^at-test; ^bchi-square-test, ^cu-test

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