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Table 3 Patient, treatment and volume characteristics in patients with and without unacceptable deviation (UD)

From: Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance

Variable Patients without UD
(n = 18)
Patient with UD
(n = 4)
p-value*
Gender
 Female 4/18 (22%) 1/4 (25%) 1.000
 Male 14/18 (78%) 3/4 (75%) 1.000
Median age at randomization (range) 68 (37–88) 48 (27–73) 0.121
Surgery
 No 6/18 (33%) 2/4 (50%) 0.602
 Yes 12/18 (67%) 2/4 (50%)  
Number of lesions treated by surgery
 1 11/12 (92%) 1/2 (50%)  
 2 1/12 (8%) 1/2 (50%)
SRS
 No 10/18 (56%) 2/4 (50%) 1.000
 Yes 8/18 (44%) 2/4 (50%) 1.000
Number of lesions treated by SRS
 1 6/8 (75%) 1/2 (50%)  
 2 2/8 (25%) 1/2 (50%)
Simultaneous Integrated Boost
 No 13/18 (72%) 3/4 (75%) 1.000
 Yes 5/18 (28%) 1/4 (25%)  
Number of SIB treatment
 1 2/5 (40%) 1/1 (100%)  
 2 2/5 (40%) 0
 3 1/5 (20%) 0  
Right hippocampus:
 Volume (cm3) 2.0 (0.9–3.9) 3.8 (2.1–5.7) 0.052
 Avoidance Volume (cm3) 13.6 (6.8–20.7) 17.0 (15.4–27.9) 0.080
Left hippocampus:
 Volume (cm3) 1.9 (1.0–3.3) 4.1 (2.4–4.5) 0.004
 Avoidance Volume (cm3) 13.3 (6.7–20.3) 17.5 (15.3–21.5) 0.035
Both hippocampi:
 Volume (cm3) 4.0 (2.3–7.2) 7.9 (4.5–10.0) 0.013
 Avoidance volume (cm3) 26.7 (13.5–41.0) 34.0 (31.7–49.4) 0.061
  1. *Based on Wilcoxon rank-sum test or Fisher exact test as appropriate. SIB Simultaneous Integrated Boost, SRS Stereotactic Radiosurgery