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Table 2 Patient and volume characteristics

From: Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance

  HA-WBRT
(n = 22)
Bilateral HA-WBRT
(n = 20)
Unilateral (right) HA-WBRT (n = 2)
Female 5 (23%) 5 (25%) 0
Male 17 (77%) 15 (75%) 2 (100%)
Median age (years) 65 (27–88) 65 (27–88) 69 (61–76)
≤ 65 years 11 (50%) 10 (50%) 1 (50%)
>  65 years 11 (50%) 10 (50%) 1 (50%)
Number of MBM:
 1 MBM 13 (59%) 12 (60%) 1 (50%)
 2 MBM 7 (32%) 6 (30%) 1 (50%)
 3 MBM 2 (9%) 2 (10%) 0
First treatment of MBM:
 Surgery only 10 (45%) 9 (45%) 1 (50%)
 SRS only 6 (27%) 5 (25%) 1 (50%)
 Surgery and SRS 4 (18%) 4 (20%) 0
 Exclusive SIB concurrent with HA-WBRT 2 (9%) 2 (10%) 0
SRS:
 Median volume (cm3) 2.07 (0.04–42.6) 3.01 (0.04–42.6) 0.96 (0.96)
 Median dose (Gy) 20 (14–22) 20 (14–22) 16 (16)
Volumes (cm3):
 PTV volume 1434.8 1412.7 1516.9
Median (Range) (1177–1640) (1177–1640) (1488–1545)
 R hippocampus volume 2.27 2.27 2.54
Median (Range) (0.9–5.66) (0.90–5.66) (1.80–3.27)
 L hippocampus volume 2.02 1.96 2.58
Median (Range) (1.01–4.45) (1.01–4.45) (2.58)
 Volume of 2 hippocampus 4.47 4.38 5.85
Median (Range) (2.28–9.98) (2.28–9.98) (5.85)
 Sparing volume of 2 hippocampus 29.52 28.53 34.77
Median (Range) (13.4–49.4) (13.4–49.4) (34.7)
Details of the SIB treatment: n = 6 n = 5 n = 1
 1 MBM 3 (50%) 3 (60%) 0
 2 MBM 2 (33%) 1 (20%) 1
 3 MBM 1 (17%) 1 (20%) 0
 Median volume (cm3) 5.71 (0.54–29.9) 5.71 (0.74–29.9) 6.26 (0.54–11.97)
 Median dose (Gy) 49.5 (40–50.4) 47.3 (40–50.4) 50 (50)
 Median distance to nearest hippocampus (cm) 2.8 (0–5.0) 3.8 (2.0–5.0) 0.3 (0–0.6)
  1. Bilateral/Unilateral HA-WBRT: Patients treated with intention to spare bilateral/unilateral hippocampus, HA-WBRT Hippocampal avoidance during whole brain radiotherapy, Hippo Hippocampus, MBM Melanoma brain metastases, PTV Planning target volume, SIB Simultaneous integrated boost, SRS Stereotactic radiosurgery, WBRT Whole brain radiotherapy