Table 1 Baseline characteristics of all patients and by adverse event grade
All | 2 or less n = 49 | 3 or greater n = 7 | ||||
|---|---|---|---|---|---|---|
n | n | % or 95% CI | n | % or 95% CI | p-value | |
Clinical characteristics | ||||||
Age at start of radiation treatment1 | 53.4 | 53.6 | 49.6–57.8 | 51.8 | 40.7–62.9 | 0.961 |
Histology | 44 | 89.8 | 7 | 100 | 1.00 | |
Squamous cell carcinoma | 51 | |||||
Adenocarcinoma | 4 | 4 | 8.2 | 0 | 0 | |
Adenosquamous | 1 | 1 | 2.0 | 0 | 0 | |
FIGO stage | 9 | 18.4 | 0 | 0 | 0.236 | |
IB1 | 9 | |||||
IB2 | 14 | 13 | 26.5 | 1 | 14.3 | |
IIA1 | 0 | 0 | 0 | 0 | 0 | |
IIA2 | 1 | 1 | 2.0 | 0 | 0 | |
IIB | 16 | 13 | 26.5 | 3 | 42.9 | |
IIIA | 0 | 0 | 0 | 0 | 0 | |
IIIB | 15 | 13 | 26.5 | 2 | 28.6 | |
IVA | 1 | 0 | 0 | 1 | 14.3 | |
N stage | 15 | 30.6 | 2 | 28.6 | 1.00 | |
N0 | 17 | |||||
N1 – pelvic nodes | 39 | 34 | 69.4 | 5 | 71.4 | |
M stage | 39 | 79.6 | 7 | 100 | 0.719 | |
M0 | 46 | |||||
M1 – para-aortic nodes | 8 | 8 | 16.3 | 0 | ||
Unknown | 2 | 2 | 4.1 | 0 | ||
Clinical tumor size at diagnosis (cm)1 | 5.4 | 5.4 | 4.6 – 6.1 | 5.5 | 4.3–6.7 | 0.742 |
ECOG | 31 | 63.3 | 7 | 100 | 0.558 | |
0 | 38 | |||||
1 | 9 | 9 | 18.4 | 0 | 0 | |
2 | 6 | 6 | 12.2 | 0 | 0 | |
3 | 2 | 2 | 4.1 | 0 | 0 | |
4 | 1 | 1 | 2.0 | 0 | 0 | |
Treatment characteristics | ||||||
Acute toxicity grade | – | |||||
0 | 45 | 45 | 91.8 | 0 | 0 | |
1 | 3 | 3 | 6.1 | 0 | 0 | |
2 | 1 | 1 | 2.0 | 0 | 0 | |
3 | 5 | 0 | 0 | 5 | 71.4 | |
4 | 2 | 0 | 0 | 2 | 28.6 | |
Chronic toxicity grade | 0.008 | |||||
0 | 36 | 35 | 71.4 | 1 | 14.3 | |
1 | 5 | 3 | 6.1 | 2 | 28.6 | |
2 | 5 | 4 | 8.2 | 1 | 14.3 | |
3 | 10 | 7 | 14.3 | 3 | 42.9 | |
4 | 0 | 0 | 0 | 0 | 0 | |
Treatment Response | 0.914 | |||||
Stable Disease | 5 | 5 | 10.2 | 0 | 0 | |
Complete Response | 20 | 18 | 36.7 | 2 | 28.6 | |
Partial Response | 21 | 19 | 38.8 | 3 | 42.9 | |
Progression | 5 | 4 | 8.2 | 1 | 14.3 | |
Unknown | 4 | 3 | 6.1 | 1 | 14.3 | |
Treatment Duration | 0.700 | |||||
Greater than 56 days | 27 | 23 | 46.9 | 4 | 57.1 | |
56 days or less | 29 | 26 | 53.1 | 3 | 42.9 | |
Ovoid Size | 0.236 | |||||
Large | 1 | 1 | 2.0 | 0 | 0 | |
Medium | 15 | 15 | 30.6 | 0 | 0 | |
Mini | 8 | 6 | 12.2 | 2 | 28.6 | |
Small | 30 | 25 | 51.0 | 5 | 71.4 | |
Unknown | 2 | 2 | 4.1 | 0 | 0 | |
Comorbidities | ||||||
Smoker | 24 | 49.0 | 1 | 14.3 | 0.149 | |
Never | 25 | |||||
Former | 9 | 8 | 16.3 | 1 | 14.3 | |
Current | 22 | 17 | 34.7 | 5 | 71.4 | |
Diabetes Mellitus | 1.00 | |||||
No | 50 | 43 | 87.8 | 7 | 100 | |
Yes | 6 | 6 | 12.2 | 0 | 0 | |