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Table 2 Association between distance metrics using recursive partitioning analysis derived cut-points and each breath-hold end point using accuracy, sensitivity and specificity (binary distance metrics) and concordance index and Pearson correlation coefficients (continuous distance metrics). Pearson correlation coefficients calculated using continuous breath-hold end points

From: Evaluation of a new predictor of heart and left anterior descending artery dose in patients treated with adjuvant radiotherapy to the left breast

Breath-Hold End Points:

Heart V25 Gy ≥ 10 cm3

Mean Heart Dose ≥1.7 Gy

Maximum LAD Dose ≥28 Gy

Variables (mm)

Mean ± SD

n (%)

Acc

Sens

Spec

C

PCC

Acc

Sens

Spec

C

PCC

Acc

Sens

Spec

C

PCC

Contact Heart

78.3 ± 22.8

0.76

0.31b

0.87

0.32b

0.84

0.49b

 <  73 mm

 ≥ 73 mm

18 (36)

32 (64)

70.0

87.0

55.6

80.0

77.5

90.0

82.0

81.1

84.6

 < 50 mma

 ≥ 50 mma

5 (10)

45 (90)

56.0

100

18.5

82.0

95.0

30.0

80.0

97.3

30.8

4th Arch

32.8 ± 25.5

0.86

0.57b

0.97

0.61b

0.91

0.55b

 <  7 mm

 ≥ 7 mm

11 (22)

39 (78)

68.0

100

40.7

94.0

95.0

90.0

88.0

94.6

69.2

5th Arch

58.5 ± 23.4

0.68

0.12

0.82

0.16

0.76

0.40b

 <  41 mm

 ≥ 41 mm

9 (19)

39 (81)

54.0

90.9

26.9

82.0

92.1

60.0

78.0

91.7

50.0

  1. LAD Left anterior descending coronary artery, Acc Accuracy, Sens Sensitivity, Spec Specificity, C Concordance index, PCC Pearson correlation coefficient;
  2. a50 mm cut-point identified previously and for comparison purposes only (not identified from recursive partitioning analysis)
  3. bp <  0.05