Skip to main content

Table 2 ᅟ

From: Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck – clinical results from the cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”

 

Univariate

Multivariate

HR

95% CI

p-Value

HR

95% CI

p-Value

Local failure (LF)

 HPVOPC

0.128

0.017-0.945

0.044*a

0.146

0.019-1.115

0.064

 ≥T3

1.580

0.731-3.413

0.244

-

-

-

 ECE vs N+ b

2.849

1.014-8.007

0.047*a

2.262d

0.711-7.199

0.167

 N+ vs N0 b

0.350

0.129-0.946

0.039*a

0.555d

0.173-1.779

0.322

 pos. Marginsc

2.730

1.016-7.333

0.046*a

3.354

1.206-9.329

0.020*a

 LVI

1.660

0.696-3.962

0.253

-

-

-

 PNI

2.853

1.137-7.154

0.025*a

2.590

1.014-6.616

0.047*a

 Rec. Tumor

1.730

0.519-5.761

0.372

-

-

-

Locoreginal failure (LRF)

 HPVOPC

0.208

0.050-0.868

0.031*a

0.210

0.049-0.894

0.035*a

 ≥T3

1.470

0.742-2.912

0.270

-

-

-

 ECE vs N+

2.855

1.167-6.985

0.022*a

2.939

1.155-7.473

0.024*a

 N+ vs N0

0.398

0.165-0.960

0.040*a

0.468

0.167-1.312

0.149

 pos. margins

1.610

0.781-3.317

0.197

-

-

-

 LVI

2.063

0.984-4.323

0.055

2.214

0.967-5.067

0.060

 PNI

1.844

0.779-4.363

0.164

-

-

-

 Rec. Tumor

1.309

0.399-4.289

0.657

-

-

-

Distant failure (DF)

 HPVOPC

0.267

0.082-0.870

0.028*a

0.153

0.036-0.644

0.010*a

 ≥T3

1.573

0.838-2.850

0.158

-

-

-

 ECE vs N+

3.408

1.621-7.164

0.001*a

3.109

1.369-7.035

0.007*a

 N+ vs N0

0.812

0.336-1.957

0.642

0.759

0.287-2.004

0.578

 pos. margins

0.774

0.411-1.458

0.428

-

-

-

 LVI

1.947

0.995-9.810

0.052

1.963

0.932-4.137

0.076

 PNI

1.463

0.634-3.372

0.372

-

-

-

 Rec. Tumor

0.319

0.044-2.324

0.259

-

-

-

Any failure (AF)

 HPVOPC

0.232

0.084-0.643

0.005*a

0.161

0.050-0.523

0.002*a

 ≥T3

1.629

0.973-2.728

0.064

1.476d

0.822-2.648

0.192

 ECE vs N+

3.126

1.668-5.858

<0.001*a

3.113

1.566-6.187

0.001*a

 N+ vs N0

0.604

0.305-1.195

0.148*a

0.669

0.302-1.484

0.323

 pos. margins

1.018

0.603-1.719

0.947

-

-

-

 LVI

1.943

1.107-3.412

0.021*a

1.996

1.071-3.720

0.030*a

 PNI

1.609

0.820-3.155

0.166

-

-

-

 Rec. Tumor

0.949

0.344-2.622

0.920

-

-

-

Overall survival (OS)

 HPVOPC

0.277

0.134-0.573

0.001*a

0.254

0.116-0.557

0.001*a

 ≥T3

1.385

0.926-2.072

0.113

-

-

-

 ECE vs N+

1.684

1.065-2.663

0.027*a

1.393

0.834-2.327

0.205

 N+ vs N0

1.127

0.675-1.883

0.647

1.984

1.091-3.610

0.025*a

 pos. margins

0.745

0.497-1.116

0.154

-

-

-

 LVI

1.284

0.799-2.064

0.302

-

-

-

 PNI

1.666

0.995-2.790

0.052

1.462d

0.853-2.506

0.167

 Rec. Tumor

0.816

0.357-1.864

0.630

-

-

-

Disease specific survival (DSS)

 HPVOPC

0.076

0.010-0.557

0.011*a

0.079

0.011-0.576

0.012*a

 ≥T3

1.839

1.003-3.373

0.049*a

1.719

0.910-3.250

0.095

 ECE vs N+

2.837

1.366-5.892

0.005*a

2.160

1.021-4.571

0.044*a

 N+ s N0

0.668

0.300-1.486

0.322

1.093

0.484-2.463

0.831

 pos. margins

0.522

0.220-1.239

0.140

-

-

-

 LVI

1.628

0.832-3.187

0.155

-

-

-

 PNI

1.791

0.842-3.812

0.130

-

-

-

 Rec. Tumor

0.965

0.298-3.124

0.953

-

-

-

Disease free survival (DFS)

 HPVOPC

0.300

0.156-0.575

<0.001*a

0.294

0.146-0.590

0.001*a

 ≥T3

1.463

1.005-2.130

0.047*a

1.369d

0.873-2.146

0.171

 ECE vs N+

2.003

1.305-3.077

0.001*a

1.876

1.159-3.035

0.010*a

 N+ vs N0

1.001

0.618-1.621

0.997

1.684

0.949-2.985

0.075

 pos. margins

1.191

0.778-1.824

0.420

-

-

-

 LVI

1.512

0.985-2.322

0.059

1.170d

0.718-1.906

0.528

 PNI

1.604

0.984-2.613

0.058

1.236d

0.733-2.081

0.427

 Rec. Tumor

0.854

0.397-1.836

0.685

-

-

-

  1. aP-values < 0.05 were marked with asterisk
  2. bNodal positive patients with ECE have been compared against nodal positive patients without ECE (ECE vs N+) and nodal positive patients without ECE against patients without nodal disease (N+ vs N0) to calculate the excess risk of ECE to nodal disease only
  3. cClose margin vs R0 was neither significant in univariate (HR = 2.200, p = 0.128), nor in multivariate (HR 1.113, p = 0.865) Factors eliminated during the backward-selection are shown for the sake of completeness in grey letters in multivariate analysis
  4. dFactors eliminated during the backward-selection are shown for the sake of completeness in multivariate analysis
Back to article page

Radiation Oncology

ISSN: 1748-717X

Contact us