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Table 2 ᅟ

From: Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck – clinical results from the cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”

  Univariate Multivariate
HR 95% CI p-Value HR 95% CI p-Value
Local failure (LF)
 HPVOPC 0.128 0.017-0.945 0.044*a 0.146 0.019-1.115 0.064
 ≥T3 1.580 0.731-3.413 0.244 - - -
 ECE vs N+ b 2.849 1.014-8.007 0.047*a 2.262d 0.711-7.199 0.167
 N+ vs N0 b 0.350 0.129-0.946 0.039*a 0.555d 0.173-1.779 0.322
 pos. Marginsc 2.730 1.016-7.333 0.046*a 3.354 1.206-9.329 0.020*a
 LVI 1.660 0.696-3.962 0.253 - - -
 PNI 2.853 1.137-7.154 0.025*a 2.590 1.014-6.616 0.047*a
 Rec. Tumor 1.730 0.519-5.761 0.372 - - -
Locoreginal failure (LRF)
 HPVOPC 0.208 0.050-0.868 0.031*a 0.210 0.049-0.894 0.035*a
 ≥T3 1.470 0.742-2.912 0.270 - - -
 ECE vs N+ 2.855 1.167-6.985 0.022*a 2.939 1.155-7.473 0.024*a
 N+ vs N0 0.398 0.165-0.960 0.040*a 0.468 0.167-1.312 0.149
 pos. margins 1.610 0.781-3.317 0.197 - - -
 LVI 2.063 0.984-4.323 0.055 2.214 0.967-5.067 0.060
 PNI 1.844 0.779-4.363 0.164 - - -
 Rec. Tumor 1.309 0.399-4.289 0.657 - - -
Distant failure (DF)
 HPVOPC 0.267 0.082-0.870 0.028*a 0.153 0.036-0.644 0.010*a
 ≥T3 1.573 0.838-2.850 0.158 - - -
 ECE vs N+ 3.408 1.621-7.164 0.001*a 3.109 1.369-7.035 0.007*a
 N+ vs N0 0.812 0.336-1.957 0.642 0.759 0.287-2.004 0.578
 pos. margins 0.774 0.411-1.458 0.428 - - -
 LVI 1.947 0.995-9.810 0.052 1.963 0.932-4.137 0.076
 PNI 1.463 0.634-3.372 0.372 - - -
 Rec. Tumor 0.319 0.044-2.324 0.259 - - -
Any failure (AF)
 HPVOPC 0.232 0.084-0.643 0.005*a 0.161 0.050-0.523 0.002*a
 ≥T3 1.629 0.973-2.728 0.064 1.476d 0.822-2.648 0.192
 ECE vs N+ 3.126 1.668-5.858 <0.001*a 3.113 1.566-6.187 0.001*a
 N+ vs N0 0.604 0.305-1.195 0.148*a 0.669 0.302-1.484 0.323
 pos. margins 1.018 0.603-1.719 0.947 - - -
 LVI 1.943 1.107-3.412 0.021*a 1.996 1.071-3.720 0.030*a
 PNI 1.609 0.820-3.155 0.166 - - -
 Rec. Tumor 0.949 0.344-2.622 0.920 - - -
Overall survival (OS)
 HPVOPC 0.277 0.134-0.573 0.001*a 0.254 0.116-0.557 0.001*a
 ≥T3 1.385 0.926-2.072 0.113 - - -
 ECE vs N+ 1.684 1.065-2.663 0.027*a 1.393 0.834-2.327 0.205
 N+ vs N0 1.127 0.675-1.883 0.647 1.984 1.091-3.610 0.025*a
 pos. margins 0.745 0.497-1.116 0.154 - - -
 LVI 1.284 0.799-2.064 0.302 - - -
 PNI 1.666 0.995-2.790 0.052 1.462d 0.853-2.506 0.167
 Rec. Tumor 0.816 0.357-1.864 0.630 - - -
Disease specific survival (DSS)
 HPVOPC 0.076 0.010-0.557 0.011*a 0.079 0.011-0.576 0.012*a
 ≥T3 1.839 1.003-3.373 0.049*a 1.719 0.910-3.250 0.095
 ECE vs N+ 2.837 1.366-5.892 0.005*a 2.160 1.021-4.571 0.044*a
 N+ s N0 0.668 0.300-1.486 0.322 1.093 0.484-2.463 0.831
 pos. margins 0.522 0.220-1.239 0.140 - - -
 LVI 1.628 0.832-3.187 0.155 - - -
 PNI 1.791 0.842-3.812 0.130 - - -
 Rec. Tumor 0.965 0.298-3.124 0.953 - - -
Disease free survival (DFS)
 HPVOPC 0.300 0.156-0.575 <0.001*a 0.294 0.146-0.590 0.001*a
 ≥T3 1.463 1.005-2.130 0.047*a 1.369d 0.873-2.146 0.171
 ECE vs N+ 2.003 1.305-3.077 0.001*a 1.876 1.159-3.035 0.010*a
 N+ vs N0 1.001 0.618-1.621 0.997 1.684 0.949-2.985 0.075
 pos. margins 1.191 0.778-1.824 0.420 - - -
 LVI 1.512 0.985-2.322 0.059 1.170d 0.718-1.906 0.528
 PNI 1.604 0.984-2.613 0.058 1.236d 0.733-2.081 0.427
 Rec. Tumor 0.854 0.397-1.836 0.685 - - -
  1. aP-values < 0.05 were marked with asterisk
  2. bNodal positive patients with ECE have been compared against nodal positive patients without ECE (ECE vs N+) and nodal positive patients without ECE against patients without nodal disease (N+ vs N0) to calculate the excess risk of ECE to nodal disease only
  3. cClose margin vs R0 was neither significant in univariate (HR = 2.200, p = 0.128), nor in multivariate (HR 1.113, p = 0.865) Factors eliminated during the backward-selection are shown for the sake of completeness in grey letters in multivariate analysis
  4. dFactors eliminated during the backward-selection are shown for the sake of completeness in multivariate analysis