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Table 3 List of detected positron emission tomography agents

From: Clinical trials involving positron emission tomography and prostate cancer: an analysis of the ClinicalTrials.gov database

Positron Emission Tomography Agent as Stated in ClinicalTrials.gov

Radionuclid

IUPAC name of the carrier or other relevant source

Number of trials

Acetate

(11C)a

Acetate

22

Choline

(11C)a

2-Hydroxy-N,N,N-trimethylethan-1-aminium

16

Choline

(18F)a

2-Hydroxy-N,N,N-trimethylethan-1-aminium

37

Choline

NOSa

2-Hydroxy-N,N,N-trimethylethan-1-aminium

7

Citrate

(68Ga)

2-Hydroxypropane-1,2,3-tricarboxylic acid

1

DFO-huJ591

(89Zr)

Recombinant humanized monoclonal antibody J591 conjugated to chelator desferrioxamine B

1

DFO-MSTP2109A

(89Zr)

Desferrioxamine - DFO-MSTP2109A is an antibody that works against STEAP1 - found on the surface of prostate cancer cells

1

DHT

(18F)a

(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

3

DOTA-Bombesin

(68Ga)

68Ga-DOTA-Bombesin is a gallium-68-labeled gastrin-releasing peptide receptor (GRPr) antagonist. DOTA is [4,7,10-Tris-(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]-acetyl.

1

DOTATET

(68Ga)

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (also known as DOTA)

1

FAZA

(18F)

Nitroimidazole nucleoside analogue 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole (FAZA)

2

FDG

(18F)a

2-Deoxy-2-[18F]fluoroglucose

15

FLT

(18F)

1-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

1

Fluciclovine

(18F)

Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid

13

Fluciclovine

(NOS)

Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid

1

Fluorocholine

(18F)

Fluoromethyl-(2-hydroxyethyl)-dimethylazanium;chloride

1

FMAU

(18F)

2′-deoxy-2′-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (fluorine F 18 d-FMAU [18F-FMAU]),

3

MeAIB

(NOS)a

2-methyl-2-(methylamino)propanoic acid

1

Methionine

(11C)a

(2S)-2-amino-4-methylsulfanylbutanoic acid

3

MISO

(18F)

1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol

1

NaF

(18F)a

Sodium;fluoride

20

NODAGA-MJ9

(Ga-68)a

1,4,7-triazacyclononane,1-glutaric acid-4,7 acetic acid (NODAGA)

1

NOTA-BBN-RGD

(68Ga)

1,4,7-triazacyclononanetriacetic acid (NOTA), Arg-Gly-Asp (RGD) and bombesin (BBN)

1

P15–041

(68Ga)

Unknown

1

PACAP

(64Cu)

Pituitary adenylate cyclase-activating peptide

2

Peripheral Benzodiazepine Receptor-28

(11C)

Peripheral Benzodiazepine Receptor-28

1

PSMA DCFPyL

(18F)a

N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-[18F]fluorobenzyl-L-cysteine ([18F]DCFBC)

21

PSMA

(68Ga)

Glutamate carboxypeptidase II, also known as N-acetyl-L-aspartyl-L-glutamate peptidase I

15

PSMA

(89Zr)

Glutamate carboxypeptidase II, also known as N-acetyl-L-aspartyl-L-glutamate peptidase I

2

PSMA CTT 1057

(NOS)

Cancer Targeted Technology (CTT), a privately held Seattle-based biotechnology firm that will develop the agent, CTT1057. CTT1057 is a small molecule that homes in and binds irreversibly to prostate specific membrane antigen (PSMA)

1

PSMA DCFBC

(18F)

(N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-F-fluorobenzyl-L-cysteine) (F-DCFBC)

4

PSMA Df-IAB2M

(89Zr)

Zr-89-desferrioxamine-IAB2M

1

RM2

(68Ga)

68Ga-RM2 stands for Galium-68 labeled DOTA-4-amino-1-carboxymethylpiperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2

3

Sodium Fluoride

(18F)

Sodium Fluoride

1

uPAR NOTA

(68Ga)

Urokinase Plasminogen Activator Receptor

1

  1. aAgent was an optional or was compared to other agent in more than one trial