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Table 1 Patient characteristics, n = 20 (PTVhom = PTV homogenous, PTVext = PTVextended, PTVboost = PTV simultaneous integrated boost, CTVhom = CTV homogenous, CTVext = CTV extended)

From: Recurrence pattern analysis after [68Ga]-DOTATATE-PET/CT -planned radiotherapy of high-grade meningiomas

Characteristic

Patients

Sex

 Male

14 (70%)

 Female

6 (30%)

Median age (range)

61 years (26–79)

Age < 50 years

6 (30%)

Median follow-up [months], 95%-CI

31.0 (20.1–42)

Surgery pre-RT

14 (70%)

 Gross total resection

10 (50%)

 Subtotal

3 (15%)

 Debulking

1 (5%)

Simpson grade of resection

 I

9 (45%)

 II

1 (5%)

 III

0

 IV

3 (15%)

 V

1 (5%)

Recurrence patterns

 No recurrence

16 (80%)

 In-field recurrence

3 (15%)

 Marginal recurrence

0

 Ex-field recurrence

1 (5%)

Median dose of RT [Gy]

60 (59.4–60.0)

Median interval between PET-scan and RT [months]

1.3 (0–9)

WHO grade

 II

16 (80%)

 III

4 (20%)

Localization

 Frontal

14 (70%)

 Frontoparietal

3 (15%)

 Frontotemporal

1 (5%)

 Parietooccipital/occipital

2 (10%)

Technique

 Step-and-shoot-IMRT (# SIB)

18 (90%)/6 (SIB)

 3D

2 (10%)

Median safety margin GTV → CTVhom or CTVext

15 mm (2–20 mm)

Median safety margin CTV → PTVhom or PTVext [mm]

4 (2–7)

Median safety margin GTV → PTVboost [mm]

3 (0–10)

Mean GTV size [ml]

64.5 (14.8–192.7)

Mean PTV size [ml]

 PTVext or PTVhom

301.5 (83.7–743.0)

 PTVboost

190.3 (20.5–586.2)