| | | Basic OLR analysis | Multivariate OLR analysis |
|---|
| | Variable | OR | 95%CI | p-value | OR | 95%CI | p-value |
|---|
Anxiety Change | Con. | 1.000 | | Ref. | 1.000 | | Ref. |
Int. | 1.384 | (0.774–2.474) | 0.273 | 1.244 | (0.668–2.316) | 0.492 |
normal | 1.000 | | Ref. | 1.000 | | Ref. |
borderline | 4.825 | (2.423–9.611) | <.001 | 4.178 | (1.991–8.764) | 0.000 |
abnormal | 16.350 | (5.619–47.573) | <.001 | 34.295 | (9.329–126.078) | <.001 |
Depression Change | Con. | 1.000 | | Ref. | 1.000 | | Ref. |
Int. | 1.611 | (0.891–2.910) | 0.114 | 1.415 | (0.743–2.696) | 0.291 |
normal | 1.000 | | Ref. | 1.000 | Ref. | |
borderline | 9.847 | (4.909–19.753) | <.001 | 11.559 | (5.381–24.829) | <.001 |
abnormal | 46.383 | (16.756–128.397) | <.001 | 45.999 | (15.546–136.104) | <.001 |
- OLR ordered logistic regression, OR odd ratio, 95%CI 95% confidence interval, Con. control, Ref. reference, Int. intervention arm
- aA few patients were excluded from the basic and multivariable OLR modeling because of their absence of anxiety or depression score changes or TNM stage missing status; covariates in multivariable OLR analysis include age, education, BMI, TNM stage, income level, breast tumor side, and surgery type;
- bAll score tests for the proportional odds assumption were insignificant (p > 0.20), which indicated that they met the requirements of using ordered logistic regressions. Basic model consisted of independent variables of study arm and three categories of anxiety or depression severity category at baseline (i.e. before radiotherapy)
- c At end, the collapsed groups of ‘Stage III and IV’ and ‘no and elementary school’ had generated the reliable estimates of OR for multivariable OLR analyses on three levels of score-based anxiety and depression categories – ‘normal’, ‘borderline’ and ‘abnormal’; Age and BMI as continuous measurements were incorporated into the multivariable models; statistically, OR refers to the event-occurring odd associated with one-level increase of these ordered categories
- dReference groups at OLR analyses are the ‘control’ group of study arm, ‘Stage III and IV’ of TNM stage, ‘college and up’ of education level, ‘right-sided’ of breast tumor side, and ‘BCS’ of surgery type where BCS means the breast conserving surgery
