Fig. 4

For all patients NTCP values for bladder and rectum were presented for all plans. The middle bars represent the mean values and the upper and lower bars the standard deviations. Wilcoxon matched pairs signed-rank test showed that no significant differences in NTCP values for the different Plans when dose was delivered in analogy to the Pinkawa protocol (p > 0.05). When dose was delivered in analogy to the Flame trial a significant reduction in NTCP-rectum values was observed for Plan95^MRI compared to Plan95^union (p = 0.012) and Plan95^PET (p = 0.047). There were no significant differences in NTCP-bladder values for Plan95 (p > 0.05)