Skip to main content
Fig. 6 | Radiation Oncology

Fig. 6

From: Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response

Fig. 6

a H&E stained sections of shielded and irradiated tumors from the same section of a mouse brain 11 days after radiotherapy at 16 and 24 Gy (10X magnification). Scale bar = 1 mm. b Quantification of tumor cell density 11 days after radiotherapy. The densities of tumor cells treated with 16 and 24 Gy were significantly lower than their corresponding un-treated side. There was also a significant difference between treated tumors at 16 and 24 Gy. c DAPI staining of shielded and irradiated tumor nuclei from the same section of a mouse brain 11 days after radiotherapy at 16 and 24 Gy. Scale bar = 50 μm. d Average size of tumor nuclei 11 days after radiotherapy normalized by that of the respective un-irradiated halves. There was a significant difference between the sizes of tumor nuclei treated with 16 and 24 Gy compared to the contralateral side. The size of tumor nuclei was also significantly different between 16 and 24 Gy. ** = p ≤ 0.01, *** = p ≤ 0.001, **** = p ≤ 0.0001, error bar indicates standard error of mean

Back to article page