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Fig. 5 | Radiation Oncology

Fig. 5

From: Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response

Fig. 5

a MR images (bSSFP) of the mouse brain at two-time points. Metastases appear as hyper-intense (bright) regions compared to brain parenchyma. Pre-treatment images are on day 26 and images on day 37 are for the same mouse 11 days after radiation therapy. Right half of the brain was irradiated. One mouse per radiation group is shown. Red arrows indicate the brain metastases in the irradiated side while green arrows show brain metastases in the un-irradiated side. b Mean fractional growth of brain metastases measured on MR images for the radiation doses normalized to that of the un-irradiated halves. Tumors irradiated with 16 and 24 Gy grew with significantly different growth rates than their respective un-irradiated sides (Kruskal-Wallis followed by Mann-Whitney U test). No difference was observed between irradiated tumors of 16 and 24 Gy. *** = p ≤ 0.001, error bar indicates standard error of the mean

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