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Table 4 Prognostic factors for (a) any type of recurrence and (b) loco-regional recurrence

From: Patterns of failure after resection of extrahepatic bile duct cancer: implications for adjuvant radiotherapy indication and treatment volumes

(a) Any type of recurrence

 Univariable analysis

  Characteristics

OR

95% CI

p value

  N0 vs N+

3.241

1.191–4.567

< 0.001

  Others vs AD

0.102

0.023–0.456

0.003

  WD-MD vs PD

2.164

1.185–3.951

0.012

  LVI Yes vs No

0.566

0.325–0.987

0.045

  PNI Yes vs No

0.385

0.219–0.677

0.001

  R0 vs close RM-R1

3.351

1.923–5.841

< 0.001

 Multivariable analysis

  Characteristics

OR

95% CI

p value

  N0 vs N+

2.533

1.420–4.518

0.002

  R0 vs close RM-R1

2.685

1.517–4.753

0.001

(b) loco-regional recurrence

 Univariable analysis

  Characteristics

OR

95% CI

p value

  R0 vs close RM-R1

3.124

1.933–5.442

< 0.001

 Multivariable analysis

  Characteristics

OR

95% CI

p value

  R0 vs close RM-R1

2.382

1.416–4.243

< 0.001

  1. OR odds ratio, CI confidential interval, vs versus, N0 negative lymph node, N+ positive lymph node, AD adenocarcinoma, WD well differentiation, MD moderate differentiation, PD poor differentiation, LVI lymphovascular invasion, PNI perineural invasion, RM resection margin