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Table 3 Univariate analysis of associations between dosimetric factors and grade ≥ 3 RP (n = 67)

From: The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation

Variable

Grade 0–2 (n = 49)

Grade ≥ 3 (n = 18)

P value

Initial-V5

  

0.047

  ≥ 53.15%

22 (44.9%)

13 (72.2%)

 

  < 53.15%

27 (55.1%)

5 (27.8%)

 

Initial-V20

  

0.152

  ≥ 18.04%

23 (46.9%)

12 (66.7%)

 

  < 18.04%

26 (53.1%)

6 (33.3%)

 

Initial-V50

  

0.633

  ≥ 2.04%

24 (49.0%)

10 (55.6%)

 

  < 2.04%

25 (51.0%)

8 (44.4%)

 

Initial-MLD

  

0.002

  ≥ 10.87

20 (40.8%)

15 (83.3%)

 

  < 10.87

29 (59.2%)

3 (16.7%)

 

Re-V5

  

0.001

  ≥ 32.7%

19 (38.8%)

15 (83.3%)

 

  < 32.7%

30 (61.1%)

3 (16.9%)

 

Re-V20

  

0.114

  ≥ 9.94%

22 (44.9%)

12 (66.7%)

 

  < 9.94%

27 (55.1%)

6 (33.3%)

 

Re-V50

  

0.532

  ≥ 1.25%

26 (53.1%)

8 (44.4%)

 

  < 1.25%

23 (46.9%)

10 (55.6%)

 

Re-MLD

  

0.001

  ≥ 6.63

19 (38.8%)

15 (83.3%)

 

  < 6.63

30 (61.2%)

13 (16.7%)

 

Composite-V5

  

< 0.001

  ≥ 68.13%

18 (36.7%)

16 (88.9%)

 

  < 68.13%

31 (63.3%)

2 (11.1%)

 

Composite-V20

  

0.033

  ≥ 28.04%

21 (42.9%)

13 (72.2%)

 

  < 28.04%

28 (57.1%)

5 (27.8%)

 

Composite-V50

  

0.304

  ≥ 7.23%

23 (46.9%)

11 (61.1%)

 

  < 7.23%

26 (53.1%)

7 (38.9%)

 

Composite-MLD

  

0.114

  ≥ 17.31

22 (44.9%)

12 (66.7%)

 

  < 17.31

27 (55.1%)

6 (33.3%)

 

Overlap-V5/Re-V5

  

0.035

 0–0.4

12 (24.5%)

2 (11.1%)

1.000*

 0.4–0.8

10 (20.4%)

10 (55.6%)

0.014*

 0.8–1

27 (55.1%)

6 (33.3%)

 
  1. Abbreviations: RP radiation pneumonitis, Initial initial radiation plan, MLD mean lung dose, Re reirradiation plan, Composite composite plan, Overlap-V5/Re-V5 the overlap between V5 of initial RT and V5 of re-RT plans/V5 of re-RT plans, Vx percent volume of lung exposed to at least x Gy, * compared with overlap-V5/Re-V5 of 0.8–1