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Table 2 Univariate analysis of associations between patient characteristics and grade ≥ 3 RP (n = 67)

From: The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation

Variable Grade 0–2 Grade ≥ 3 P value
  (N = 49) (N = 18)  
Sex    0.584
 Male 36 (73.5%) 12 (66.7%)  
 Female 13 (26.5%) 6 (33.3%)  
Age    0.822
  ≥ 65 15 (30.6%) 5 (27.8%)  
  < 65 34 (69.4%) 13 (72.2%)  
Smoking    0.797
 Yes 31 (63.3%) 12 (66.7%)  
 No 18 (36.7%) 6 (33.3%)  
Pathologic type    0.856
 NSCLC 26 (53.1%) 10 (55.6%)  
 SCLC 23 (46.9%) 8 (44.4%)  
Prior thoracic surgery    0.364
 Yes 11 (16.4%) 6 (9%)  
 No 38 (56.7%) 12 (17.9%)  
ECOG PS before Re-RT    0.914
 0–1 44 (89.9%) 17 (94.4%)  
 2 5 (10.2%) 1 (5.6%)  
Chemotherapy    0.246
 Yes 12 (24.5%) 7 (38.9%)  
 No 37 (75.5%) 11 (61.1%)  
Median Time to Re-RT    0.114
  ≥ 15.57 22 (44.9%) 12 (66.7%)  
  < 15.57 27 (55.1%) 6 (33.3%)  
Initial technique    1
 Conventional 47 (95.9%) 18 (100%)  
 SBRT 2 (4.1%) 0 (0%)  
Re-RT technique    0.213
 Conventional 42 (85.7%) 18 (100%)  
 SBRT 7 (14.3%) 0 (0%)  
Re-RT location    0.822
 Central 34 (69.4%) 13 (72.2%)  
 Peripheral 15 (30.6%) 5 (27.8%)  
Re-RT location    0.114
 In field 27 (55.1%) 6 (33.3%)  
 Outside 22 (44.9%) 12 (66.7%)  
  1. Abbreviations: RP radiation pneumonitis, NSCLC non-small cell lung cancer, SCLC small cell lung cancer, SBRT stereotactic ablative radiation therapy, Re-RT reirradiation