Table 2 Univariate analysis of associations between patient characteristics and grade ≥ 3 RP (n = 67)
Variable | Grade 0–2 | Grade ≥ 3 | P value |
|---|---|---|---|
(N = 49) | (N = 18) | ||
Sex | 0.584 | ||
Male | 36 (73.5%) | 12 (66.7%) | |
Female | 13 (26.5%) | 6 (33.3%) | |
Age | 0.822 | ||
≥ 65 | 15 (30.6%) | 5 (27.8%) | |
< 65 | 34 (69.4%) | 13 (72.2%) | |
Smoking | 0.797 | ||
Yes | 31 (63.3%) | 12 (66.7%) | |
No | 18 (36.7%) | 6 (33.3%) | |
Pathologic type | 0.856 | ||
NSCLC | 26 (53.1%) | 10 (55.6%) | |
SCLC | 23 (46.9%) | 8 (44.4%) | |
Prior thoracic surgery | 0.364 | ||
Yes | 11 (16.4%) | 6 (9%) | |
No | 38 (56.7%) | 12 (17.9%) | |
ECOG PS before Re-RT | 0.914 | ||
0–1 | 44 (89.9%) | 17 (94.4%) | |
2 | 5 (10.2%) | 1 (5.6%) | |
Chemotherapy | 0.246 | ||
Yes | 12 (24.5%) | 7 (38.9%) | |
No | 37 (75.5%) | 11 (61.1%) | |
Median Time to Re-RT | 0.114 | ||
≥ 15.57 | 22 (44.9%) | 12 (66.7%) | |
< 15.57 | 27 (55.1%) | 6 (33.3%) | |
Initial technique | 1 | ||
Conventional | 47 (95.9%) | 18 (100%) | |
SBRT | 2 (4.1%) | 0 (0%) | |
Re-RT technique | 0.213 | ||
Conventional | 42 (85.7%) | 18 (100%) | |
SBRT | 7 (14.3%) | 0 (0%) | |
Re-RT location | 0.822 | ||
Central | 34 (69.4%) | 13 (72.2%) | |
Peripheral | 15 (30.6%) | 5 (27.8%) | |
Re-RT location | 0.114 | ||
In field | 27 (55.1%) | 6 (33.3%) | |
Outside | 22 (44.9%) | 12 (66.7%) |