|
Outcome
|
PTV coverage prioritized
|
OAR constraints prioritized
|
|---|
|
50 Gy in 5
|
60 Gy in 8
|
60 Gy in 15
|
50 Gy in 5
|
60 Gy in 8
|
60 Gy in 15
|
|---|
|
tumor control
|
92.9 (89.7–99.1)
|
92.4 (84.7–95.3)
|
52.0 (48.3–55.7)
|
60.3 (31.5–80.1)
|
65.7 (39.2–81.4)
|
47.8 (41.0–53.3)
|
|
acute esophagitis ≥ grade 2
|
1.18 (0.45–3.98)
|
1.05 (0.44–2.44)
|
0.86 (0.42–1.85)
|
0.72 (0.34–1.35)
|
0.77 (0.39–1.40)
|
0.72 (0.42–1.49)
|
|
symptomatic pneumonitis (all grades)
|
4.30 (1.79–11.6)
|
4.09 (1.90–11.1)
|
3.68 (1.53–13.8)
|
3.44 (2.24–8.03)
|
3.45 (1.75–8.08)
|
2.97 (1.54–6.84)
|
|
pericarditis or pericardial effusion
|
0.01 (0.00–0.08)
|
0.00 (0.00–0.00)
|
0.00 (0.00–0.00)
|
0.00 (0.00–0.00)
|
0.00 (0.00–0.00)
|
0.00 (0.00–0.00)
|
|
proximal bronchial tree toxicity (grade 4 or 5)
|
49.7 (15.0–70.0a)
|
42.7 (5.0–70.0a)
|
4.0 (0.0–10.0)
|
0.0 (0.0–0.0)
|
0.0 (0.00–0.0)
|
1.3 (0.0–5.0)
|
|
uncomplicated tumor control
|
46.7 (27.6–77.6)
|
53.5 (25.4–90.4)
|
49.9 (44.6–54.0)
|
60.3 (31.5–80.1)
|
65.7 (39.2–81.4)
|
47.2 (41.0–52.8)
|
- Cells are average (range) tumor control probability or normal tissue complication probability (%). a4 cases had an EQD2 greater than the range presented by Cannon et al and it is therefore likely that their risk is greater than 70%
