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Table 2 Inter-correlations of EBV-DNA, hematologic inflammatory markers, T&N classification, and GTV

From: Pretreatment prognostic factors of survival and late toxicities for patients with nasopharyngeal carcinoma treated by simultaneous integrated boost intensity-modulated radiotherapy

  

EBV-DNA

T classificationa

N classificationa

GTV

Median (range)

γ

γ

γ

γ

Neutrophil, %

63.1 (31.7–86.1)

0.09

0.10

−0.04

−0.07

Lymphocyte, %

28.4 (10.0–51.3)

−0.27**

0.11

0.03

−0.01

Monocyte, %

5.6 (0.8–11.7)

0.28**

0.10

0.01

0.18*

Platelet, 109/l

236 (112–498)

0.20*

0.07

0.07

0.27**

N/L ratio

2.21 (0.62–8.61)

0.14

−0.08

−0.04

−0.02

L/M ratio

5.04 (1.25–21.25)

−0.29**

−0.05

0.05

−0.17*

P/L ratio

8.43 (3.14–37.60)

0.32**

−0.01

0.01

0.18*

EBV-DNA, copies/ml

106 (0–94,920)

–

0.04

0.31**

0.39**

  1. N/L ratio neutrophil to lymphocyte ratio, L/M ratio lymphocyte-to-monocyte ratio, P/L ratio platelet to lymphocyte ratio, EBV Epstein-Barr virus, GTV gross tumor volume
  2. *p < 0.01, ** p < 0.001, γ: correlation coefficient
  3. aAccording to the AJCC 7th staging system