Comparison of efficacy and safety of preoperative Chemoradiotherapy in locally advanced upper and middle/lower rectal cancer

Table 3 Comparision of toxicity and treatment breaks in 3DCRT and IG-IMRT groups

Acute toxicity			3DCRT^a		IG-IMRT^b		Intra-goup	Inter-group
Acute toxicity			n = 44	(%)	n = 129	(%)	P-value	P-value
Skin	Middle/Lower rectum	Grade 0	17	58.6	57	66.3	0.204	0.103
		Grade 1	8	27.6	24	27.9
		Grade 2	2	6.9	3	3.5
		Grade 3	2	6.9	2	2.3
	Upper rectum	Grade 0	9	60	33	76.7	0.216
		Grade 1	6	40	10	23.3
		Grade 2	0	0	0	0
		Grade 3	0	0	0	0
GI^c	Middle/Lower rectum	Grade 0	13	44.8	48	55.8	0.284	0.071
		Grade 1	8	27.6	21	24.4
		Grade 2	4	13.8	9	10.5
		Grade 3	4	13.8	8	9.3
	Upper rectum	Grade 0	6	35.7	25	58.1	0.099
		Grade 1	4	28.6	12	27.9
		Grade 2	3	21.4	4	9.3
		Grade 3	2	14.3	2	4.7
GU^d	Middle/Lower rectum	Grade 0	24	82.8	79	91.9	0.014	0.016
		Grade 1	2	6.9	7	8.1
		Grade 2	1	3.4	0	0
		Grade 3	2	6.9	0	0
	Upper rectum	Grade 0	15	100	43	100	–
		Grade 1	0	0	0	0
		Grade 2	0	0	0	0
		Grade 3	0	0	0	0
Leukocytosis	Middle/Lower rectum	Grade 0–2	29	100	86	100	–	–
		Grade 3	0	0	0	0
	Upper rectum	Grade 0–2	15	100	43	100	–
		Grade 3	0	0	0	0
Hemoglobin	Middle/Lower rectum	Grade 0	7	24.1	27	31.4	0.522	0.448
		Grade 1	13	44.8	37	43
		Grade 2	8	27.6	18	20.9
		Grade 3	1	3.5	4	4.7
	Upper rectum	Grade 0	3	20	10	23.3	0.593
		Grade 1	5	33.3	20	46.5
		Grade 2	6	40	8	18.6
		Grade 3	1	6.7	5	11.6
RT^e ≥ 40 days	Middle/Lower rectum	Yes	2	6.9	5	5.8	0.834	0.733
		No	27	93.1	81	94.2
	Upper rectum	Yes	1	6.7	2	4.7	0.764
		No	14	93.3	41	95.3

^aThree-dimensional conventional radiotherapy; ^bimage guided intensity modulated radiotherapy; ^cGastrointestinal tract; ^dgenitourinary tract; ^eRT: radiotherapy

ISSN: 1748-717X