Comparison of efficacy and safety of preoperative Chemoradiotherapy in locally advanced upper and middle/lower rectal cancer

Table 2 Patient characteristics in upper rectum and middle/lower rectum groups

Characteristics	Total		Upper		Middle/Lower		P-value
Characteristics	N	(%)	n = 58	(%)	n = 115	(%)
Pathologic tumor depth
ypT0	39	22.5	11	19	28	24.3	0.076
ypT1	16	9.2	4	6.9	12	10.4
ypT2	43	24.9	12	20.7	31	27
ypT3	72	41.6	29	50	43	37.4
ypT4a	1	0.6	0	0	1	0.9
ypT4b	2	1.2	2	3.4	0	0
Pathologic lymph node metastasis
ypN0	132	76.3	47	81	85	73.9	0.105
ypN1a	17	9.8	6	10.3	11	9.6
ypN1b	10	5.8	3	5.2	7	6.1
ypN1c	5	2.9	1	1.7	4	3.5
ypN2a	6	3.5	1	1.7	5	4.3
ypN2b	3	1.7	0	0	3	2.6
Pathologic complete response
Yes	39	22.5	11	19	28	24.3	0.424
No	134	77.5	47	81	87	75.7
Median number of resected nodes	11 (0–25)		11(5–25)		11 (0–23)		0.91
Median number of involved nodes	0(0–9)		0 (0–4)		0(0–9)
Tumor regression grade
0	39	22.5	11	19	28	24.3	0.371
1	58	33.5	27	46.6	31	27
2	52	30.1	14	24.1	38	33
3	24	13.9	6	10.3	18	15.7
Circumferential resection margin
Negative	167	96.5	55	94.8	112	97.4	0.404
Positive	6	3.5	3	5.2	3	2.6
Perineural invasion
Negative	140	80.9	47	81	93	80.9	0.979
Positive	33	19.1	11	19	22	19.1
Lymphovascular invasion
Negative	152	87.9	52	89.7	100	87	0.608
Positive	21	12.1	6	10.3	15	13.413
Tumor differentiation
Well	13	7.5	4	6.9	9	7.8	0.996
Moderately	153	88.4	52	89.7	101	87.8
Poorly	7	4	2	3.4	5	4.4
Pathologic T stage
Downstaging	112	64.7	34	58.6	78	67.8	0.462
Stable	55	31.8	23	39.7	32	27.8
Progressive	6	3.5	1	1.7	5	4.3
Pathologic N stage
Downstaging	117	67.6	41	70.7	76	66.1	0.21
Stable	48	27.7	17	29.3	31	26.9
Progressive	8	4.6	0	0	8	7
Pathologic TN stage
Downstaging	142	82.1	50	86.2	92	80	0.115
Stable	23	13.3	8	13.8	15	13
Progressive	8	4.6	0	0	8	7

ISSN: 1748-717X