Image-guided radiotherapy reduces the risk of under-dosing high-risk prostate cancer extra-capsular disease and improves biochemical control

Table 3 Univariate and Multivariate Cox model analysis data predicting for PRFS. Significant covariates in the univariate and multivariate model are printed in bold typeface

Cox model analysis Variables	Univariate analysis	Multivariate analysis
Cox model analysis Variables	p-value	Hazard Ratio	95% CI	p-value
Overall model				0.001
T-Stage	0.083	ns
Gleason	0.127	ns
Pre-RT PSA	0.012	ns
Number of NCCN risk factors^a	0.008	2.15	(1.17–3.95)	0.013
Rectal Cross-section	0.558	ns
Neo-adjuvant HT	0.395	ns
Expected dose to the CTV	0.143	ns
Candidate ECD descriptor^b	0.005	3.88	(1.26–1 1.99)	0.0 18

^aPre-treatment PSA10+, G7+ and T2c+
^bInteraction term: probability of low dose (10 Gy less than prescription dose) and probability of extra-capsular disease at about 1 cm dorso-laterally of the prostate gland

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