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Table 2 Summary of the mean and one standard deviation of the dosimetric parameters obtained with GTV–based prescription

From: Optimizing the prescription isodose level in stereotactic volumetric-modulated arc radiotherapy of lung lesions as a potential for dose de-escalation

 

85% PIL

80% PIL

70% PIL

60% PIL

GTV D mean (Gy)

54.0 ± 0.1

53.9 ± 0.1

53.6 ± 0.2

54.0 ± 1.2

PTV D mean (Gy)

50.7 ± 0.6

49.3 ± 0.7

46.1 ± 0.9

42.9 ± 1.1

PTV D 98% (Gy)

45.9 ± 1.2

43.2 ± 0.8

38.2 ± 0.5

33.6 ± 1.1

PTV D 95% (Gy)

46.7 ± 1.1

43.9 ± 0.7

39.0 ± 0.4

34.4 ± 0.9

Spinal cord D 1% (Gy)

7.9 ± 2.6

8.1 ± 3.2

7.0 ± 2.7

a6.5 ± 2.2

Esophagus D 1% (Gy)

8.2 ± 3.0

7.8 ± 4.1

a6.9 ± 3.8

a6.1 ± 3.3

Bronchus D 1% (Gy)

11.8 ± 6.6

10.9 ± 6.2

a9.1 ± 5.2

a7.6 ± 4.5

Trachea D 1% (Gy)

4.6 ± 6.1

4.5 ± 6.1

a3.7 ± 5.0

a3.4 ± 4.6

Chest wall/Rib V30Gy (cc)

29.8 ± 27.3

18.1 ± 16.3

a12.4 ± 12.4

a6.3 ± 8.0

Heart D 1% (Gy)

9.2 ± 8.3

8.5 ± 7.5

7.2 ± 6.5

a6.3 ± 5.5

PTV minus GTV D50% (Gy)

49.8 ± 0.8

48.2 ± 0.6

a44.3 ± 0.6

a40.5 ± 0.6

PTV minus GTV V54Gy (%)

1.0 ± 1.8

1.3 ± 1.5

a0.4 ± 0.5

a0.1 ± 0.1

Normal Lung MLD (Gy)

4.4 ± 1.6

4.0 ± 1.4

a3.3 ± 1.0

a2.9 ± 0.9

Normal Lung V30Gy (%)

4.0 ± 2.6

3.1 ± 1.6

a2.2 ± 1.2

a1.7 ± 0.9

Normal Lung V20Gy (%)

7.0 ± 3.6

5.9 ± 2.6

a4.7 ± 2.2

a3.7 ± 1.7

Normal Lung V10Gy (%)

12.8 ± 4.9

11.3 ± 3.9

a9.8 ± 3.5

a9.4 ± 4.5

Normal Lung V5Gy (%)

18.2 ± 5.0

17.2 ± 4.2

a15.6 ± 3.7

a14.6 ± 3.8

  1. PIL prescription isodose line relative to the maximum dose, GTV gross target volume, PTV planning target volume, Dmean mean dose, Dx dose to x percent volume of the organ, Vx percent volume of the organ receiving at least x Gy, MU monitor unit, nCI target dose conformity index, R 50% dose gradient index. aSignificant difference from the reference 85% PIL based on PTV D95% prescription