Additional radiotherapy following endoscopic submucosal dissection for T1a-MM/T1b-SM esophageal squamous cell carcinoma improves locoregional control

Table 2 Univariate and multivariate analysis for locoregional control

				Univariate analysis	Multivariate analysis
Factors		Number	3-year LRC (%)	p-value	p-value
Age, yr	≥65	18	86	0.51	(−)
Age, yr	< 65	9	67
Gender	Male	22	78	0.46	(−)
Gender	Female	5	100
Number of primary tumors	Single	22	82	0.48	(−)
Number of primary tumors	Multiple	5	75
Invasion depth	pT1a-MM	16	71	0.24	(−)
Invasion depth	pT1b-SM1	11	90
Circumferential extent of ESD	< 3/4	17	83	0.71	(−)
Circumferential extent of ESD	≥3/4	10	77
Longitudinal diameter of ESD (mm)	< 40	13	76	0.77	(−)
Longitudinal diameter of ESD (mm)	≥40	14	83
Additional chemotherapy	(+)	8	60	0.16	0.039*
Additional chemotherapy	(−)	19	87
Additional RT	(+)	13	100	0.022*	0.0022*
Additional RT	(−)	14	58

ESD Endoscopic submucosal dissection, RT Radiotherapy, LRC Locoregional control, pT1a-MM Tumor invading muscularis mucosae, pT1b-SM1 Tumor invading submucosa less than 200 μm below the MM. *p < 0.05

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