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Table 2 Univariable and multivariable analysis of potential preditive factors. Factors with a p-value ≤0.1 were included in multivariable analysis

From: Are prognostic indices for brain metastases of melanoma still valid in the stereotactic era?

Variable

univariable analysis

multivariable analysis

HR

95% CI

p

HR

95% CI

p

UICC stage at diagnosis (<IV vs. IV)

0.63

0.355 - 1.12

0.11

   

ECM

1.59

0.69-3.69

0.28

   

Synchronous BM

1.56

0.49-5.03

0.46

   

Gender (m vs. f)

1.18

0.73 - 1.91

0.5

   

highest BED10 (< vs. > = median)

1.14

0.67-1.92

0.63

   

Age (< vs. > = median)

1.05

0.67 - 1.69

0.83

   

Cumulative BM volume (< vs. > = median)

2.486

1.5 - 4.13

< 0.001 (*)

1

0.94 - 1.06

0.87

KPS (<90% vs. > = 90%)

2.16

1.3 - 3.59

0.003 (*)

3.99

1.78 - 8.96

0.001 (*)

Single vs. multiple lesions

1.68

1.04 - 2.72

0.034 (*)

3.55

1.71 - 7.35

0.001 (*)

Histology (NM vs. other)

1.9

1.02 - 3.52

0.043 (*)

2.26

1.12 - 4.54

0.022 (*)

Interval PT diagnosis to SRT (< vs. > = median)

0.66

0.41-1.06

0.086 (+)

0.79

0.38 - 1.66

0.54

  1. UICC Union internationale contre le cancer, ECM Extracranial metastasis, BM Brain metastasis, BED Biologically effective dose, KPS Karnofsky performance status, NM Nodular melanoma, PT Primary tumor, SRT Stereotactic radiotherapy
  2. (*) p-value ≤0.05, (+) p-value ≤0.1