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Fig. 4 | Radiation Oncology

Fig. 4

From: Late normal tissue response in the rat spinal cord after carbon ion irradiation

Fig. 4

Histological sections representative for the biological endpoint paresis grade II. Cryosections stained with hemalum/eosin in combination with Luxol fast blue (a-c). A clear structural decline in the white matter represented by necrosis (asterisk) and vacuolization (open arrows) as well as hemorrhages (white arrows) and dilated blood vessels (closed black arrows) can be seen (b, c). Paraffin sections for detection of albumin extravasation (brown precipitation) combined with Nissl staining (d-f). Albumin leaks predominately in the area where structural decline of white matter occurs (black asterisks) and around the canalis centralis (white arrow heads). The leakage is more intense after carbon ion (e) than photon irradiation (f) (scale bar 200 μm)

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