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Fig. 4 | Radiation Oncology

Fig. 4

From: Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC

Fig. 4

TAE684 sensitizes ALK positive NSCLC cells to carbon ions. The surviving fraction of H3122(a), LLC (b) and A549 (c) cells was determined after vehicle or TAE684 (4 nM) treatment and carbon ion irradiation (0, 1, 2 or 4 Gy). TAE684 treatment potently sensitized ALK-positive H3122 to carbon ion radiotherapy, while a moderate radiosensitivity was induced in LLC cells and no response was observed in A549 cells. Bars indicate mean ± SD

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