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Table 2 Cox Proportional Hazards Regression Model for Overall Survival and Lung Cancer-Specific Survival in Patients based on Number Categories

From: Choice of postoperative radiation for stage IIIA pathologic N2 non-small cell lung cancer: impact of metastatic lymph node number

  No. of positive lymph nodes ≤3 No. of positive lymph nodes >3
  Overall Survival Lung Cancer-Specific Survival Overall Survival Lung Cancer-Specific Survival
Variable Hazard Ratio (95% CI) p Hazard Ratio (95% CI) p Hazard Ratio (95% CI) p Hazard Ratio (95% CI) p
Age, years
  < 65 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
  ≥ 65 1.449(1.279 to 1.643) <0.001 1.469(1.281 to 1.684) <0.001 1.345(1.152 to 1.572) <0.001 1.381(1.168 to 1.632) <0.001
Race   0.234   0.396   0.054   0.068
 White 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Black 1.030(0.849 to 1.249) 0.768 1.012(0.817 to 1.255) 0.91 0.739(0.547 to 0.998) 0.048 0.757(0.557 to 1.031) 0.077
 Other 0.832(0.668 to 1.037) 0.102 0.849(0.667 to 1.08)) 0.182 0.802(0.606 to 1.061) 0.122 0.776(0.572 to 1.052) 0.103
Sex
 Female 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Male 1.349(1.191 to 1.528) <0.001 1.366(1.192 to 1.567) <0.001 1.308(1.122 to 1.525) 0.001 1.279(1.085 to 1.507) 0.003
Primary Site   0.705   0.963   0.993   0.976
 Main bronchus 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Upper lobe 1.189(0.634 to 2.230) 0.59 0.986(0.493 to 1.969) 0.967 1.074(0.624 to 1.85) 0.796 1.18(0.656 to 2.121) 0.581
 Middle lobe 1.384(0.699 to 2.739) 0.351 1.065(0.502 to 2.26) 0.87 0.988(0.491 to 1.988) 0.973 1.096(0.523 to 2.3) 0.808
 Lower lobe 1.269(0.673 to 2.394) 0.462 1.035(0.514 to 2.084) 0.923 1.088(0.626 to 1.892) 0.765 1.195(0.658 to 2.172) 0.558
 Overlapping/ lung, NOS 1.241(0.616 to 2.500) 0.545 1.021(0.474 to 2.198) 0.957 1.055(0.535 to 2.083) 0.876 1.124(0.548 to 2.306) 0.749
Histology   0.11   0.043   0.152   0.13
 Non-small cell carcinoma 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Adenocarcinoma, NOS 0.888(0.701 to 1.125) 0.325 0.861(0.665 to 1.115) 0.257 1.129(0.836 to 1.525) 0.428 1.222(0.876 to 1.705) 0.237
 Squamous cell carcinoma, NOS 1.121(0.874 to 1.437) 0.368 1.047(0.797 to 1.375) 0.741 1.248(0.905 to 1.722) 0.177 1.456(1.018 to 2.081) 0.039
 Large cell carcinoma, NOS 1.12(0.765 to 1.64) 0.561 1.16(0.779 to 1.729) 0.465 1.778(0.867 to 3.122) 0.045 1.536(0.795 to 2.966) 0.201
Laterality
 Left 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Right 0.985(0.871 to 1.114) 0.809 1.008(0.88 to 1.154) 0.911 1.012(0.867 to 1.18) 0.882 1.05(0.889 to 1.239) 0.568
Tumor Size   0.66   0.724   0.463   0.5
  ≤ 3.0 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 3.1-5.0 1.008(0.838 to 1.213) 0.93 1.045(0.854 to 1.385) 0.671 1.068(0.849 to 1.343) 0.575 1.061(0.827 to 1.36) 0.641
 5.1-7.0 1.03(0.825 to 1.286) 0.793 1.088(0.854 to 1.385) 0.495 1.146(0.879 to 1.496) 0.314 1.13(0.85 to 1.503) 0.4
  ≥ 7.1 0.879(0.661 to 1.168) 0.374 0.936(0.684 to 1.28) 0.678 1.216(0.888 to 1.665) 0.222 1.256(0.892 to 1.767) 0.192
 Unknown 1.297(0.766 to 2.196) 0.332 1.344(0.765 to 2.362) 0.304 0.66(0.302 to 1.44) 0.296 0.692(0.316 to 1.515) 0.357
T stage   0.001   0.001   0.003   0.005
T1 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
T2 1.296(1.072 to 1.566) 0.007 1.279(1.037 to 1.578) 0.022 1.207(0.933 to 1.562) 0.151 1.223(0.925 to 1.616) 0.157
T3 1.722(1.324 to 2.239) <0.001 1.79(1.348 to 2.375) <0.001 1.769(1.291 to 2.423) <0.001 1.793(1.279 to 2.514) 0.001
Tx 1.028(0.404 to 2.614) 0.954 1.11(0.43 to 2.87) 0.829 1.172(0.312 to 4.412) 0.814 1.242(0.329 to 4.697) 0.749
No. of positive lymph codea   0.389   0.17   0.074   0.075
 1/4 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 2/5 1.038(0.902 to 1.194) 0.601 1.032(0.884 to 1.205) 0.689 1.288(1.035 to 1.604) 0.024 1.316(1.039 to 1.668) 0.023
 3/6 1.113(0.955 to 1.297) 0.169 1.172(0.991 to 1.387) 0.064 1.197(0.937 to 1.528) 0.15 1.24(0.952 to 1.616) 0.111
  ≥ 7      1.255(1.036 to 1.52) 0.02 1.275(1.036 to 1.569) 0.022
Surgery type
 Lobectomy 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Pneumonectomy 1.101(0.884 to 1.372) 0.391 1.056(0.822 to 1.358) 0.669 0.986(0.791 to 1.23) 0.903 1.025(0.812 to 1.293) 0.836
Port
 No 1.00 (reference)   1.00 (reference)   1.00 (reference)   1.00 (reference)  
 Yes 0.887(0.778 to 1.011) 0.072 0.894(0.774 to 1.033) 0.129 0.803(0.687 to 0.938) 0.006 0.794(0.671 to 0.94) 0.007
  1. Abbreviations: NOS not otherwise specified
  2. a: 4, 5, 6, ≥7, these four categoric variables were designed for hazard ratios in the right two columns