Table 1 Grading scale for inflammation, edema, hemorrhages and fibrosis

Inflammation:

0 = No inflammatory infiltration.

1 = Mild cellular infiltration with an increase of up to 10 cells per X10 HPF (high power field).

2 = Moderate cellular infiltration with an increase of 10-20 cells per X10 HPF.

3 = High cellular infiltration with an increase of 20-50 cells per X10 HPF.

4 = Very high cellular infiltration with an increase of >50 cells per X10 HPF.

Necrosis:

0 = No necrosis.

1 = Mild necrosis in the epidermis

2 = Moderate necrosis in the epidermis

3 = Severe necrosis in the epidermis

4 = Severe necrosis in the dermis and in the epidermis

Edema:

0 = No edema.

1 = Mild edema in the dermis

2 = Moderate edema in the dermis

3 = Severe edema in the dermis

4 = Severe edema in the dermis and in the epidermis

Hemorrhages:

0 = No hemorrhages at all.

1 = Mild hemorrhages in the dermis

2 = Moderate hemorrhages in the dermis

3 = Severe hemorrhages in the dermis

4 = Severe hemorrhages in the dermis and in the epidermis

Fibrosis:

0 = Dermis shows no scar formation compared to normal skin.

1 = Dermis shows very mild dermal fibrosis.

2 = Dermis shows moderate dermal fibrosis.

3 = Dermis shows high dermal fibrosis typical for scar formation.

4 = Dermis shows high dermal fibrosis with typical scar tissue contraction.