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Table 4 Effect of ATMi and DNAPKi for irradiation of A549 cells with carbon ions at indicated doses

From: Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

 

Normoxia

Hypoxia

Carbon ions

0 nM

100 nM ATMi

p-value

Ratio

0 nM

100 nM ATMi

p-value

Ratio

SF3.8Gy

0.11 ± 0.03

0.05 ± 0.01

0.03

2.13 ± 0.09

0.14 ± 0.03

0.07 ± 0.04

0.08

1.95 ± 0.64

SF5.6Gy

0.05 ± 0.01

0.02 ± 0.002

0.028

2.99 ± 0.59

0.06 ± 0.02

0.03 ± 0.02

0.14

2.15 ± 0.84

  

100 nM DNAPKi

   

100 nM DNAPKi

  

SF3.8Gy

 

0.03 ± 0.01

0.013

3.38 ± 0.34

 

0.03 ± 0.005

0.004

5.07 ± 0.02

SF5.6Gy

 

0.01 ± 0.03

0.021

4.39 ± 1.30

 

0.008 ± 0.03

0.015

7.07 ± 0.06

  1. Abbreviations: SF survival fraction at indicated dose