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Table 5 Median (range) of the dosimetric difference between the estimated delivered dose by the nominal (D pCT ), the cumulative (D cCT ) and adapted plan (D cCT, Adapt ) for the investigated 9 cases. A positive number indicates a higher value for D cCT . Significant differences (paired t-test, p < 0.05) are marked by *

From: Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes

ROI Parameter D cCT − D pCT D cCT − D cCT, Adapt
CTV Low-risk
ΔD98% / pp −0.76* −0.52*
  (−4.14–0.42) (−2.76 – −0.14)
CTV High-risk
ΔD98% / pp −1.15* −0.6*
  (−3.41–0.25) (−2.22–0.25)
ΔD2% / pp −0.34 0.37
  (−0.94–5.51) (−0.13–6.74)
Spinal Cord
ΔD1cc / Gy 0.43 −0.15
  (−0.82–1.14) (−0.22–0.79)
Brainstem
ΔD1cc / Gy 0.74* 0.22
  (−0.24–1.8) (−0.19–1.07)
Parotid Ipsilateral
ΔDmedian / Gy 0 −0.26
  (−2.66–1.78) (−1.16–0.73)
Larynx
ΔDmean / Gy 6.39* 1.69*
  (−1.51–8.86) (−0.87–9.05)
Oral Mucosa
ΔDmean / Gy −0.2 −0.23
  (−0.72–1.79) (−0.66–2.29)
Constrictor Muscles
ΔDmean / Gy 0.66 0.22
  (−2.45–4.16) (−0.86–4.26)
Esophagus
ΔDmean / Gy 0 0.13
  (−1.64–8.15) (−0.93–9.61)
  1. Abbreviations: pp. Percentage points, D 98% Minimum dose to the 98% of the target volume, D 2% Minimum dose to the 2% of the target volume, D mean Mean dose, D median Median dose