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Table 5 Median (range) of the dosimetric difference between the estimated delivered dose by the nominal (D pCT ), the cumulative (D cCT ) and adapted plan (D cCT, Adapt ) for the investigated 9 cases. A positive number indicates a higher value for D cCT . Significant differences (paired t-test, p < 0.05) are marked by *

From: Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes

ROI Parameter

D cCT − D pCT

D cCT − D cCT, Adapt

CTV Low-risk

ΔD98% / pp

−0.76*

−0.52*

 

(−4.14–0.42)

(−2.76 – −0.14)

CTV High-risk

ΔD98% / pp

−1.15*

−0.6*

 

(−3.41–0.25)

(−2.22–0.25)

ΔD2% / pp

−0.34

0.37

 

(−0.94–5.51)

(−0.13–6.74)

Spinal Cord

ΔD1cc / Gy

0.43

−0.15

 

(−0.82–1.14)

(−0.22–0.79)

Brainstem

ΔD1cc / Gy

0.74*

0.22

 

(−0.24–1.8)

(−0.19–1.07)

Parotid Ipsilateral

ΔDmedian / Gy

0

−0.26

 

(−2.66–1.78)

(−1.16–0.73)

Larynx

ΔDmean / Gy

6.39*

1.69*

 

(−1.51–8.86)

(−0.87–9.05)

Oral Mucosa

ΔDmean / Gy

−0.2

−0.23

 

(−0.72–1.79)

(−0.66–2.29)

Constrictor Muscles

ΔDmean / Gy

0.66

0.22

 

(−2.45–4.16)

(−0.86–4.26)

Esophagus

ΔDmean / Gy

0

0.13

 

(−1.64–8.15)

(−0.93–9.61)

  1. Abbreviations: pp. Percentage points, D 98% Minimum dose to the 98% of the target volume, D 2% Minimum dose to the 2% of the target volume, D mean Mean dose, D median Median dose