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Table 2 Median (range) of differences between the cumulated dose considering the anatomy in the control CTs, D cCT , and the nominal plan dose D pCT . A positive number indicates a higher value of D cCT . Significant differences (paired t-test, p < 0.05) are marked by*

From: Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes

ROI Parameter

MFOPTV

MFORob

SFOPTV

SFORob

Low-risk CTV

ΔD98% / pp

−0.09

0.16

0

0.05

 

(−3.62–0.58)

(−0.58–0.58)

(−4.14–0.76)

(−2.70–0.32)

High-risk CTV

ΔD98% / pp

0.15

−0.53

−0.18

−0.78*

 

(−1.03–1.94)

(−3.41–0.16)

(−2.50–0.16)

(−2.65 − −0.21)

ΔD2% / pp

0.18

−0.31*

−0.46*

−0.63*

 

(−0.29–5.51)

(−0.88 − −0.06)

(−0.91 − −0.13)

(−0.94 − −0.34)

Spinal Cord

ΔD1cc / Gy

0.57

0.61

0.46

0.59*

 

(−1.21–1.15)

(−0.82–1.04)

(−0.72–0.99)

(−0.80–1.22)

Brainstem

ΔD1cc / Gy

0.61

0.13

0.15

0.17

 

(−0.82–1.04)

(−0.14–1.80)

(−0.24–1.14)

(−0.17–1.39)

Parotid Ipsilateral

ΔDmedian / Gy

0.66

0.04

−0.31

−0.34

 

(−0.02–2.39)

(−1.66–1.78)

(−2.02–1.34)

(−2.66–1.34)

Larynx

ΔDmean / Gy

1.21

0.89

1.21

0.9

 

(−1.37–8.58)

(−1.28–6.60)

(−1.51–8.86)

(−1.29–6.97)

Oral Mucosa

ΔDmean / Gy

−0.05

0.02

0.01

0.06

 

(−0.48–1.79)

(−0.20–1.61)

(−0.72–1.72)

(−0.71–1.54)

Constrictor Muscles

ΔDmean / Gy

0.1

−0.11

0.05

0.05

 

(−2.05–2.83)

(−2.09–2.35)

(−2.45–4.16)

(−2.24–2.91)

Esophageal inlet

ΔDmean / Gy

0.57

0.44

0.57

0.5

 

(−1.67–7.84)

(−1.20–5.23)

(−1.64–8.15)

(−1.28–5.53)

  1. Abbreviations: pp. Percentage points, D 98% Minimum dose to the 98% of the target volume, D 2% Minimum dose to the 2% of the target volume, D mean Mean dose, D median Median dose