Fig. 2

Imaging for the survey cases. a Case 1: a small in-field recurrence with a reasonably favorable location in a young patient who was 2 years out from chemoirradiation and had not been rechallenged with additional systemic agents. b Case 2: a small edge of field, biopsy proven recurrence in a reasonably favorable location in a younger patient almost 2 years out from treatment who had also failed Bevacizumab treatment. c Case 3: a larger in field recurrence, in an unfavorable location a considerable time out from treatment (11 years) who was heavily chemo-retreated, and had also failed Bevacizumab treatment. d Case 4: a very large in field recurrence in an older patient with a very good performance status who had completed chemoirradiation less than a year prior. e Case 5: a younger patient with an original histologic diagnosis of anaplastic astrocytoma who had done very well for 5 years until out of field progression was noted for which he was asymptomatic