Fig. 3

Representative axial images of color-coded power doppler ultrasound overlayed with a B-Mode image showing a middle HI-tumor section before and after selected time points after single doses: yellow and red pixels represent the blood flow. The blue contours after 72 and 78 days in the upper row represent the persisting residual tumor volume of a local controlled HI-tumor. The lower panel describes the time course of a photon treated HI-tumor without local tumor control / with a regrowing tumor showing continuous volume and blood flow increase. After carbon ion irradiation, the tumor volume reduction as well as the decrease in power doppler signal reveals a tremendous decrease in blood flow which is not seen after photon treatment at early time points