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Table 3 Comparisons of dosimetric parameters and beam delivery time

From: Normal lung sparing Tomotherapy technique in stage III lung cancer

Parameters L-IMRT TH-IMRT TD-IMRT p a
L-IMRT vs. TH-IMRT L-IMRT vs. TD-IMRT TH-IMRT vs TD-IMRT
Median (IQR) Median (IQR) Median (IQR)
PTV CI 0.75 (0.72, 0.81) 0.82 (0.79, 0.85) 0.81 (0.77, 0.83) 0.006 0.006 0.580
HI 1.08 (1.07, 1.08) 1.06 (1.05, 1.06) 1.07 (1.05, 1.07) 0.006 0.006 0.317
P-cord NTCP 0.82% (0.71, 0.92) 0.34% (0.23, 0.48) 0.43% (0.28, 0.55) 0.006 0.006 0.393
Dmax 46.44 Gy (45.56, 47.21) 44.93 Gy (40.35, 45.33) 45.55 Gy (41.41, 46.68) 0.029 0.317 0.194
Normal Lung NTCP 8.11% (4.90, 10.11) 6.42% (3.67, 7.47) 6.53% (4.95, 9.51) 0.006 1.000 0.082
Dmean 17.83 Gy (14.98, 19.16) 16.49 Gy (13.49, 17.30) 16.60 Gy (14.98, 18.78) 0.006 1.000 0.082
V5 62.46% (54.08,71.35) 61.46% (50.92, 68.01) 65.83% (58.94, 72.58) 0.006 0.393 0.006
V10 48.48% (43.71, 53.45) 43.76% (35.66, 49.68) 51.87% (45.52, 56.77) 0.006 0.967 0.006
V15 40.63% (37.17, 45.77) 34.56% (28.11, 39.09) 38.81% (34.66, 45.60) 0.006 0.580 0.001
V20 35.47% (30.92, 37.54) 28.02% (23.35, 31.08) 30.30% (27.79, 34.55) 0.006 0.006 0.006
V30 23.99% (20.37, 26.77) 19.65% (16.30, 21.70) 19.75% (17.69, 21.23) 0.006 0.029 0.580
V40 13.26% (12.07, 18.24) 13.61% (11.35, 15.94) 12.63% (11.78, 14.91) 1.000 1.000 1.000
Heart NTCP 27.70% (23.75, 33.50) 27.24% (23.90, 33.10) 27.44% (24.07, 32.40) 1.000 1.000 1.000
V45 6.71% (0.95, 21.71) 4.10% (0.20, 11.15) 4.66% (0.90, 10.06) 0.023 0.023 1.000
V60 1.92% (0.04, 7.02) 1.65% (0.00, 4.25) 1.41% (0.05, 4.53) 0.117 0.047 1.000
Esophagus NTCP 35.57% (21.88, 46.54) 33.05% (17.92, 42.89) 36.91% (22.89, 45.17) 0.252 1.000 0.082
V50 41.79% (24.36, 48.55) 38.43% (18.63, 48.17) 42.77% (22.23, 49.65) 0.059 0.580 0.393
V60 29.55% (10.26, 38.90) 25.28% (9.35, 39.00) 30.25% (11.75, 39.26) 0.146 1.000 0.018
Beam delivery time 8.4 min (6.98, 10.18) 10.1 min (9.05, 11.90) 7.3 min (6.23, 8.90) 0.252 0.375 0.006
  1. CI conformity index, HI homogeneity index, V D the percentage of organ volume receiving D Gy or higher, D mean mean dose, D max maximum dose, NTCP normal tissue complication probability, IQR interquartile range (Q1, Q3)
  2. aThe Wilcoxon signed rank test was used by the Bonferroni correction for multiple testing