Table 5 Summary of SBRT Reirradiation Literature
Study | N | Location | SBRT Dose (Gy) | Fx | LC | OS | Toxicity | |
|---|---|---|---|---|---|---|---|---|
Kelly et al. [14] | 37 | In-field & Out-of-field | Unspecified | 40 – 50 | 4 | 92.0% (2y) | 59.0% (2y) | 33.0% Grade 3 0.0% Grade 4 0.0% Grade 5 |
Kilburn et al. [15] | 33a | In-field | Central & Peripheral | 20 – 54 | 1 – 10 | 67.0% (2y) | 45.0% (2y) | 3.0% Grade 3 0.0% Grade 4 3.0% Grade 5 |
Trakul et al. [16] | 15 | In-field | Central & Peripheral | 20 – 50 | 1 – 5 | 65.5% (1y) | 80.0% (1y) | 11.6% Grade 2/3 0.0% Grade 4 0.0% Grade 5 |
Owen et al. [17] | 18 | In-field & Out-of-field | Central & Peripheral | 40 – 60 | 3 – 10 | 90.0% (2y) | 88.0% (1y) | 0.0% Grade 3 0.0% Grade 4 0.0% Grade 5 |
Parks et al. [18] | 27 | In-field & Out-of-field | Central & Peripheral | 30 – 54 | 3 – 5 | 72.0% (2y) | 79.0% (2y) | 25.9% Grade 3 3.7% Grade 4 0.0% Grade 5 |
Patel et al. [19] | 26 | In-field & Out-of-field | Central & Peripheral | 15 – 50 | 3 – 5 | 78.6% (1y) | 52.3% (1y) | 0.0% Grade 3 0.0% Grade 4 0.0% Grade 5 |
Reyngold et al. [20] | 39 | In-field & Out-of-field | Unspecified | 20 – 60 | 1 – 5 | 77.0% (1y) | 22 mo. (med.) | 10.3% Grade 3 2.6% Grade 4 0.0% Grade 5 |
Trovo et al. [21] | 17 | In-field | Central | 30 | 5 – 6 | 86.0% (1y) | 59.0% (1y) | 23.0% Grade 3 0.0% Grade 4 11.8% Grade 5 |
Present Study | 20 | In-field | Ultra-central | 25 – 45 | 5 | 30.0% (1y) | 45.0% (1y) | 5.0% Grade 3 0.0% Grade 4 5.0% Grade 5 |
≥40 | 5 | 66.7% (1y) | 77.8% (1y) | |||||