Comparison of volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with conventional radiotherapy in preoperative chemoradiation for rectal cancers: a propensity score case-matched analysis

Table 1 Clinicopathological characteristics after PSM

Factors	3D–CRT		SIB-VMAT		p value
	N	Rate	N	Rate
Total	120		60
Age
Median	64 y.o.		66 y.o.		0.81
Range	32–83 y.o.		44–88 y.o.		0.81
Sex
Female	41	34%	17	28%	0.43
Male	79	66%	43	72%	0.43
Clinical T stage
cT2	10	8%	3	5%	0.23
cT3	101	84%	48	80%
cT4	9	8%	9	15%
Clinical N stage
cN0	67	56%	25	42%	0.102
cN1–2	53	44%	35	58%
cN0	67	56%	25	42%	0.053
cN1	29	24%	25	42%
cN2	24	20%	10	17%
Clinical stage
c-II	65	54%	25	42%	0.11
c-III	55	46%	35	58%	0.11
Distance from AV
Median	5 cm		4 cm		0.56
Range	0–12 cm		0–12 cm		0.56
Serum CEA value
Median	6.4		7.2		0.78
Range	1.2–231.8		1.5–93.1		0.78
Combined CPT-11
With	14	12%	6	10%	0.74
Without	106	88%	54	90%	0.74
Location of primary tumor
Upper rectum	36	30%	11	18%	0.0053
Lower rectum	73	61%	33	55%
Anal canal	11	9%	16	27%
Histopathological type
Well-differentiated
adenocarcinoma	65	54%	37	62%	0.34
Others	55	46%	23	38%	0.34

ISSN: 1748-717X