Table 3 Clinical parameters in patients with radiation pneumonitis ≥ Grade 3 and ≤ Grade 2
Characteristic | Total No. of Patients (N = 100) | No. of ≥ Grade 3 RP Patients (N = 15) | No. of ≤ Grade 2 RP Patients (N = 85) | P Value |
|---|---|---|---|---|
Median age (range), y | 72 (39–89) | 71 (62–80) | 72 (39–89) | 0.988 |
Male sex | 82 (82) | 14 (93.3) | 68 (81.9) | 0.453 |
Disease stage | 0.0398 | |||
1 | 25 (25) | 0 (0) | 25 (29.4) | |
2 | 9 (9) | 2 (13.3) | 7 (8.2) | |
3 | 51 (51) | 11 (73.3) | 40 (47.1) | |
4 | 15 (15) | 2 (13.3) | 13 (15.3) | |
a Histology type | 0.0479 | |||
SqCC | 33 (33) | 10 (66.7) | 23 (27.1) | |
Adenocarcinoma | 27 (27) | 2 (13.3) | 25 (29.4) | |
SCC | 15 (15) | 3 (20.0) | 12 (14.1) | |
NSCC | 8 (8) | 0 (0) | 8 (9.4) | |
Unknown | 14 (14) | 0 (0) | 14 (16.4) | |
Others | 3 (3) | 0 (0) | 3 (3.5) | |
Treatment type | 1.000 | |||
IMRT | 5 (5) | 0 (0) | 5 (5.9) | |
3D Conformal | 95 (95) | 15 (100) | 80 (94.1) | |
aChemotherapy | 0.0082 | |||
Yes | 40 (40) | 11 (73.3) | 29 (34.1) | |
No | 60 (60) | 4 (26.7) | 56 (65.9) | |
Smoking history | 0.174 | |||
Current | 24 (24) | 1 (6.7) | 23 (27.1) | |
Former | 59 (59) | 12 (80.0) | 47 (55.3) | |
Never | 17 (17) | 2 (13.3) | 15 (17.6) | |
Smoking (range), pack-years | 40 (0–180) | 52 (0–120) | 39 (0–180) | 0.118 |
Median BMI (range), kg/m2 | 20.30 | 20.91 | 19.98 | 0.126 |
(14.98–27.40) | (16.19–24.83) | (14.98–27.40) | ||
aILD | 0.0420 | |||
Yes | 6 (6) | 3 (20.0) | 3 (3.5) | |
No | 94 (94) | 12 (80.0) | 82 (96.5) | |
Surgery | 0.0783 | |||
No surgery | 95 (95) | 13 (86.7) | 82 (96.5) | |
Pre-RT | 1 (1) | 1 (6.7) | 0 (0) | |
Post-RT | 4 (4) | 1 (6.7) | 3 (3.5) | |
Median MLD (IQR), Gy | 7.200 | 10.717 | 5.896 | <0.0001 |
(3.676–10.572) | (8.590–17.610) | (3.474–9.308) | ||
Median V20% (IQR) | 13.554 | 20.522 | 12.626 | <0.0001 |
(5.872–20.449) | (15.336–27.924) | (5.039–18.328) | ||
Median LAV% (IQR) | 0.103 | 0.085 | 0.112 | 0.798 |
(0.026–0.257) | (0.035–0.254) | (0.021–0.260) |