Table 2 Clinical parameters in symptomatic radiation pneumonitis patients and asymptomatic patients
Characteristic | Total No. of Patients (N = 100) | No. of Symptomatic Patients (≥ grade 2 RP) (N = 27) | No. of Asymptomatic Patients (≤ grade 1 RP) (N = 73) | P Value |
|---|---|---|---|---|
Median age (range), y | 72 (39–89) | 70 (59–82) | 73 (39–89) | 0.248 |
Male sex | 82 (82) | 25 (92.6) | 57 (80.3) | 0.221 |
Disease stage | 0.003 | |||
1 | 25 (25) | 1 (3.7) | 24 (32.9) | |
2 | 9 (9) | 2 (7.4) | 7 (9.6) | |
3 | 51 (51) | 21 (77.8) | 30 (41.1) | |
4 | 15 (15) | 3 (11.1) | 12 (16.4) | |
a Histology type | 0.060 | |||
SqCC | 33 (33) | 12 (44.4) | 21 (28.8) | |
Adenocarcinoma | 27 (27) | 5 (18.5) | 22 (30.1) | |
SCC | 15 (15) | 7 (25.9) | 8 (11.0) | |
NSCC | 8 (8) | 2 (7.4) | 6 (8.2) | |
Unknown | 14 (14) | 1 (3.7) | 13 (17.8) | |
Others | 3 (3) | 0 (0) | 3 (4.1) | |
Treatment type | 0.103 | |||
IMRT | 5 (5) | 0 (0) | 5 (6.8) | |
3D Conformal | 95 (95) | 27 (100) | 68 (93.2) | |
Chemotherapy | <0.0001 | |||
Yes | 40 (40) | 20 (74.1) | 20 (27.4) | |
No | 60 (60) | 7 (25.9) | 53 (72.6) | |
Smoking history | 0.196 | |||
Current | 24 (24) | 10 (37.0) | 14 (19.2) | |
Former | 59 (59) | 13 (48.2) | 46 (63.0) | |
Never | 17 (17) | 4 (14.8) | 12 (17.8) | |
Smoking (range), pack-years | 40 (0–180) | 45 (0–120) | 36 (0–180) | 0.195 |
Median BMI (range), kg/m2 | 20.3 (14.98–27.40) | 20.55 (16.19–24.83) | 20.16 (14.98–27.40) | 0.395 |
ILD | 0.0358 | |||
Yes | 6 (6) | 4 (14.8) | 2 (2.7) | |
No | 94 (94) | 23 (85.2) | 71 (97.3) | |
Surgery | 0.3142 | |||
None | 95 (95) | 25 (92.6) | 70 (95.9) | |
Pre-RT | 1 (1) | 1 (3.7) | 0 (0) | |
Post-RT | 4 (4) | 1 (3.7) | 3 (4.1) | |
Median MLD (IQR), Gy | 7.2 (3.676–10.572) | 11.416 (8.615–16.801) | 4.854 (3.338–8.146) | <0.0001 |
Median V20% (IQR) | 13.554 (5.872–20.449) | 21.153 (17.092–30.368) | 10.314 (4.802–14.529) | <0.0001 |
Median LAV% (IQR) | 0.103 (0.026–0.257) | 0.095 (0.037–0.254) | 0.108 (0.018–0.279) | 0.907 |